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Information of uptake and metabolism after oral application was obtained from a study in rats (Huntington, 2006), wheras information on absorption through the skin was obtained from a study in mice (Huntington, 2006). Both studies were performed under GLP and according to OECD testing guidelines 417 and 427, respectively. 14C-labelled substance was used for tracing.

Upon single oral dosing, a total of 3 metabolites in the freshly prepared urine pools of animals treated with 50 mg/kg bw were identified via molecular weight and fragmentation pattern using a mass spectrometer operating in the negative electrospray mode (ESI LC/MS). Metabolites in the other urine and fecal fractions were correlated to these identified metabolites via their retention times. Upon sacrifice after 7 days, less than 0.3% radioactivity were detected in tissues at 0.5 and 50 mg/kg bw, respectively.

Upon single dermal exposure, the absorption rate was calculated to be 4.42 % at 6 h (The absorbable fraction of test substance was calculated as the sum of excreta, tissues, treated skin after stripping and stratum corneum in percent of applied radioactivity.) Mean tissue concentrations of radioactivity in carcass, gastrointestinal tract and treated skin corresponded to 2.26%, 0.03% and 0.07% of applied dose.

Based on the experimental data, the substance is considered to be non bioaccumulating.