Registration Dossier
Registration Dossier
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EC number: 481-080-8 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method by Stern M et al.: Toxicology in vitro 12, 455-461 (1998); EpiOcular Tissue Model
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- Method by Stern: MTT assay; viability (%); ET50 > 60 min
- Time point:
- other: 3, 30, 60 min
- Score:
- 91 - 101
- Reversibility:
- other: not relevant: in vitro assay
- Remarks on result:
- other: EpiOcular Tissue Model
- Irritant / corrosive response data:
- An ET50 value of T-126 was determined to be above 60 min.
Applicant's summary and conclusion
- Conclusions:
- T-126 should be categorized as non/minimal irritant.
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