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EC number: 222-048-3 | CAS number: 3327-22-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Rapporteur for the EU risk assessment of (3-chloro-2-hydroxypropyl)trimethylammonium chloride is the National Product Control Agency for Welfare and Health, Finland. The report is the result of in-depth work performed by experts in one Member State, working with counterparts in other Member States, Industry and public interest groups. The information reported is considered reliable.
Data source
Reference
- Reference Type:
- other: Published secondary source
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Details of the guideline followed not given
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- EC Number:
- 222-048-3
- EC Name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- Cas Number:
- 3327-22-8
- Molecular formula:
- C6H15ClNO.Cl
- IUPAC Name:
- 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
- Reference substance name:
- (3-chloro-2-hydroxypropyl)trimethylammoniumchloride
- IUPAC Name:
- (3-chloro-2-hydroxypropyl)trimethylammoniumchloride
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The percutaneous absorption of (3-chloro-2-hydroxypropyl)trimethylammonium chloride was examined in a study which used a 2-14C radiolabelled test substance and viable human and mouse skin membranes. The tests were conducted using four concentrations : 0.1, 1, 20 and 65% (3-chloro-2-hydroxypropyl)trimethylammonium chloride. 14C testostrone was used as the reference compound. The amount of test substance in the receptor fluid and the residual (3-chloro-2-hydroxypropyl)trimethylammonium chloride remaining in the skin and the stratum corneum 48-h post exposure were determined. In the viable human skin membranes, the amount of radioactivity in the skin after tape stripping was between 0.5 and 6.8 fold higher than the amount in the receptor fluid. The amount found in stratum corneum was between 1.1 to 21 times higher than what was found in the receptor fluid. In mouse skin, the amount of radioactivity in skin after tape stripping was 5.3 to 17.6 times lower than the amount of radioactivity in the receptor fluid. The mean recovery of radioactivity was between 91.2 and 102.2% in mouse and human skin membranes. Based on the findings in the in-vitro skin penetration assay, a maximum penetration rate of 0.685% was reached in the human skin.
- Executive summary:
The percutaneous absorption of (3-chloro-2-hydroxypropyl)trimethylammonium chloride was examined in a study which used a 2-14C radiolabelled test substance and viable human and mouse skin membranes. The tests were conducted using four concentrations : 0.1, 1, 20 and 65% (3-chloro-2-hydroxypropyl)trimethylammonium chloride. 14C testostrone was used as the reference compound. The amount of test substance in the receptor fluid and the residual (3-chloro-2-hydroxypropyl)trimethylammonium chloride remaining in the skin and the stratum corneum 48-h post exposure were determined. In the viable human skin membranes, the amount of radioactivity in the skin after tape stripping was between 0.5 and 6.8 fold higher than the amount in the receptor fluid. The amount found in stratum corneum was between 1.1 to 21 times higher than what was found in the receptor fluid. In mouse skin, the amount of radioactivity in skin after tape stripping was 5.3 to 17.6 times lower than the amount of radioactivity in the receptor fluid. The mean recovery of radioactivity was between 91.2 and 102.2% in mouse and human skin membranes. Based on the findings in the in-vitro skin penetration assay, a maximum penetration rate of 0.685% was reached in the human skin. [Source : European Union Risk Assessment Report for (3-Chloro-2-hydroxypropyl)trimethylammonium Chloride, 2008].
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