Registration Dossier
Registration Dossier
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EC number: 936-023-6 | CAS number: 950782-86-2
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Solubility in organic solvents Guideline 92/69/EEC, appendix A.6. OECD-Guideline 105 EPA Product Properties Guideline OPPTS 830.7840
- Principles of method if other than guideline:
- flask method
- GLP compliance:
- yes (incl. QA statement)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Solubility in organic solvents Guideline 92/69/EEC, appendix A.6. OECD-Guideline 105 EPA Product Properties Guideline OPPTS 830.7840
- Principles of method if other than guideline:
- flask method
- GLP compliance:
- yes (incl. QA statement)
Referenceopen allclose all
Results of the preliminary range-finding tests
Solvent |
Solubility at 20°C g / L |
Heptane * |
< 12.5 |
Toluene * |
< 12.5 |
Dichloromethane |
50 - 125 |
Ethanol * |
< 12.5 |
Acetone |
25-50 |
Acetonitrile * |
< 12.5 |
Ethyl acetate |
25 – 50 |
Dimethyl sulfoxide |
> 250 |
* repeated test with 0.01 g of test item
Results of the repeated test with an amount of 0.01 g test item
Solvent |
Solubility at 20°C g / L |
Heptane |
< 0.625 |
Toluene |
1.25 - 2.5 |
Ethanol |
6.25 - 12.5 |
Acetonitrile |
2.5 - 6.25 |
Final result
Solubility of AE 1170437 in organic solvents
Solvent |
Solubility at 20°C1) |
Heptane |
0.032 g/L |
Toluene |
4.3 g/L |
Dichloromethane |
150 g/L |
Ethanol |
13.0 g/L |
Acetone |
55 g/L |
Acetonitrile |
7.6 g/L |
Ethyl acetate |
47 g/L |
Dimethyl sulfoxide |
> 250 g/L |
1)Corrections with the sample purity were made (98.4 %).
Solubility of AE 1170438 in organic solvents
Solvent |
Solubility at 20°C1) |
Heptane |
0.019 g/L |
Toluene |
1.3 g/L |
Dichloromethane |
28 g/L |
Ethanol |
5.1 g/L |
Acetone |
17.3g/L |
Ethyl acetate |
47 g/L |
1)Corrections with the sample purity were made (97.9 %).
Description of key information
Solvent Solubility at 20 °C
Heptane: 0.019 - 0.032 g/L
Toluene: 1.3 - 4.3 g/L
Dichloromethane: 28 - 150 g/L
Ethanol: 5.1 - 13.0 g/L
Acetone: 17.3 - 55 g/L
Acetonitrile: 7.6 g/L
Ethyl acetate: 47 g/L
Dimethyl sulfoxide: > 250 g/L
Key value for chemical safety assessment
Additional information
flask method
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