Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-464-0 | CAS number: 99591-74-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
1,5,2,4-dioxadithiane 2,2,4,4-tetraoxide (MMDS) is rapidly hydrolized into methandisulphonic acid (MDSA) in the water. Within 104 minutes, all MMDS was hydrolized into MDSA. As a result of this, it is very difficult to prepare the test solution of MMDS. Therefore, according to the OECD guidance document, No.23, September 2000, "Guidance Document of Aquatic Toxicity testing of Difficult Substances and Mixtures", the toxicity study of Daphnia Magna with MDSA was conducted. This study was performed according to the OECD 202 Guideline.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 45 mg/L
Additional information
The test revealed a 48-hour EC50 of 45 mg/L. However, the EC50 with pH adjustment was >100 mg/L. Therefore, it was considered that the effect to the test organisms was caused by low pH. The test substance concentrations in the test solution were maintained within ±20% of the nominal concentrations during the exposure period. Although immobility in the control was 10%, the value met the criterion for the validity of the test (i.e. not more than 10%). The test conditions were within the suitable range, therefore, it was concluded that this study complied with the applied test guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
