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Diss Factsheets
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EC number: 700-464-0 | CAS number: 99591-74-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: estimation
- Adequacy of study:
- key study
- Study period:
- 15 June 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No experimental data are available. Estimations on toxicokinetics were made based on the available guidance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
- Principles of method if other than guideline:
- A statement was prepared based on the guidance on the information requirements and chemical safety assessment.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,5,2,4-dioxadithiane 2,2,4,4-tetraoxide
- EC Number:
- 700-464-0
- Cas Number:
- 99591-74-9
- Molecular formula:
- C2H4O6S2
- IUPAC Name:
- 1,5,2,4-dioxadithiane 2,2,4,4-tetraoxide
- Details on test material:
- Not applicable.
Constituent 1
Test animals
- Species:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- Not applicable.
Administration / exposure
- Route of administration:
- other: not applicable.
- Vehicle:
- other: not applicable.
- Details on exposure:
- Not applicable.
- Duration and frequency of treatment / exposure:
- Not applicable.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not applicable.
- No. of animals per sex per dose / concentration:
- Not applicable.
- Control animals:
- other: Not applicable.
- Positive control reference chemical:
- Not applicable.
- Details on study design:
- Not applicable.
- Details on dosing and sampling:
- Not applicable.
- Statistics:
- Not applicable.
Results and discussion
- Preliminary studies:
- Not applicable.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not applicable.
- Details on distribution in tissues:
- Not applicable.
- Details on excretion:
- Not applicable.
Metabolite characterisation studies
- Details on metabolites:
- Not applicable.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: no bioaccumulation, due to hydrolytical unstability.
MMDS is a solid and is hydrolytically unstable in water and aqueous solutions. Physical chemical characteristics of MMDS requiring studies in aqueous surroundings (as water solubility, octanol/water partition coefficient and surface tension) can therefore not be determined on MMDS. MMDS will decompose rapidly in formaldehyde and MSDA. As the assessment will be performed for MMDS, the toxicokinetic behavior of MSDA and formaldehyde is not further considered.
As the physical chemical properties of the substance determine the toxicokinetic properties of MMDS for a toxicokinetic assessment, and the essential values for MMDS are not available, worst-case estimates are proposed for MMDS, according to REACH guidance (1,2).
For oral absorption, the worst-case value is considered 50% (2). The results of the toxicity studies do not provide reasons to deviate from this proposed oral absorption factor.
Based on the particle size of MMDS, the mass median aerodynamic diameter of MMDS is 192.481 µm. Particles < 100 μm which have a potential to be inhaled, are present (10% < 59.316 µm and 2.26% < 10 µm). For risk assessment purposes in the scope of EU REACH, the inhalation absorption of MMDS is set at 100%, as a worst-case estimate (1,2).
Based on the relatively low molecular weight (188.179) and in the absence of a logPow, the criteria for 10% dermal absorption as given in the guidance (1) (MW > 500 and logPo/w > 4) are not met and hence 100% dermal absorption is proposed. The results of the toxicity studies do not provide reasons to deviate from this proposed dermal absorption factor.
Normally, it is generally accepted that dermal absorption is lower compared to oral absorption. However, since the 50% oral absorption is set in absence of further data, the 100% dermal absorption should therefore be considered a worst case assumption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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