Registration Dossier
Registration Dossier
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EC number: 206-337-1 | CAS number: 328-84-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
In a report (BG Chemie Toxikologische bewertungen, Nr. 89, 1997) is stated that the no adverse effected level (NOAEL) of 3,4-dichloro-α,α,α-trifluorotoluene after repeated exposure, 28- or 90-days, was between 5 and 10 mg/kg bw. Effects on the liver (centrilobular hypertrophy of the hepatocytes, increased relative liver weight) and kidneys were observed. However, the observed kidney effects were not likely to occur in humans, because it is specific for the species in which it was tested.
In a repeated dose study presented in the ECHA dissiminated dossier (d.d. 2014-08-20) Sprague-Dawley rats were exposed to 7.5, 15, 30, 60, 120 mg/kg bw 3,4-dichloro-α,α,α-trifluorotoluene, via oral gavage daily for 14 days. The NOAEL was determined to be more than 120 mg/kg bw.
Justification for classification or non-classification
Because of the limited information available for repeated dose toxicity, classification is not possible in accordance with EU Classification, Labeling and Packaging of Substance and Mixtures (CLP) Regulation No. 1272/2008 and EU Directive 67/548 (DSD).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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