Registration Dossier
Registration Dossier
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EC number: 206-337-1 | CAS number: 328-84-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
From the ECHA disseminated dossier acute toxicity is gathered (d.d. 2014-08-20). The LD50 for acute oral toxicity in rats was 1.96 mL/kg bw (2800 – 3340 mg/kg bw). The lethal concentration after 4 hours of inhalation exposure was determined to be more than 15,860 mg/m3 air for rats. The LD50 for Wistar rats exposed after dermal application (OECD 402, GLP) was determined to be more than 2000 mg/kg bw. For rabbits the LD50 was determined to be more than 5000 mg/kg bw after dermal application.
Additional information is available in a report (BG Chemie Toxikologische bewertungen, Nr. 89, 1997), in which a summation of study results is presented, for a structural analogue of 3,4-dichloro-α,α,α-trifluorotoluene. It is stated that 3-chloro-α,α,α-trifluorotoluene has a very low toxicity in rats after acute oral exposure. The LD50 was more than 5000 mg/kg bw. The LC50 after 4 hours of inhalation exposure is more than 23,600 mg/m3 air. Clinical signs observed (impairment of motor skills, effects on breathing, drowsiness, and lacrimation) were caused by effects on the central nervous system. The effects observed were reversible within 3 to 6 days after application. Body weight was not affected.
Justification for classification or non-classification
Based on the high LD50 values for both 3,4-dichloro-α,α,α-trifluorotoluene and its structural analogue 3-chloro-α,α,α-trifluorotoluene, classification for oral, inhalation and dermal acute toxicity is not warranted in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substance and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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