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EC number: 643-078-7 | CAS number: 87855-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 July - 26 October, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide
- EC Number:
- 643-078-7
- Cas Number:
- 87855-59-2
- Molecular formula:
- C11 H22 N2 O2 Si Si(CH3)(CH=CH2)[N(CH2CH3)(C(=O)CH3)]2
- IUPAC Name:
- N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide
- Test material form:
- solid: compact
- Details on test material:
- Identification: Methylvinyl bis(n-ethylacetamido)silane (supplied as Dow Corning® 1-6008)
Lot No.: 091217
CAS No.: 87855-59-2
Expiration Date: 26 December 2010
Source: Korea Biogen Co. Ltd., 690 Sinduk-Ri, Sungnam-Myuan, Chunan-City, Chungnam, 330-893, Korea
Physical Description: Amber Liquid (StultS, 2010)
Stability; Stable, refer to MSDS
Purity: 77.9 ± 0.3% area % purity (Stuns, 2010), Tested as 100%
Solubility: Unknown, andlor may be soluble in other common organic solvents
Storage Conditions: Room Temperature
Room Temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Results and discussion
Any other information on results incl. tables
The 48-hour EC50 value for methylvinyl his(n-ethy\acetamido )silane and Daplmia magna was determined using probit analysis to be 69 rng/L, with 95% confidence intervals of 57 to 88 mgIL. The highest concentration producing 0% immobilization was 25 rng/L and the lowest concentration producing 100% immobilization was> 100 mgIL. The No-Observed-Effect Concentration (NOEC) was determined to be 25 mgIL.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The No-Observed-Effect Concentration (NOEC) was determined to be 25 mg/L.
- Executive summary:
The purpose of this study was to estimate the acute toxicity of the hydrolysis products of methyl vinyl bis(n-ethylacetamido )silane to daphnids (Daphnia magna) under static conditions. Based on preliminary range-finding test results and consultation with the Study Sponsor, the daphnids were exposed to nominal concentrations of 6.3, 13,25, 50 and 100 mg/L. Due to the rapid hydrolysis of the test substance (information based on previous work and consultation with the study monitor), no attempt was made to determine the toxicity of parent substance. The results of this study are based on nominal concentrations. Twenty daphnids were exposed for 48 hours in four replicate test vessels for each concentration and the control. The immobilization in each test vessel was monitored and recorded at test initiation and after 24 and 48 hours of exposure. Temperature, pH and dissolved oxygen were measured daily during the test and were within acceptable limits. Following 48 hours of exposure, 30 and 75% immobilization was observed among daphnids exposed to the 50 and 100 mg/L treatment levels, respectively. One surviving daphnid exposed to the 100 mgIL treatment level was observed to be lethargic at test termination. No immobilization or adverse effects were observed in the remaining treatment levels tested (6.3, 13 and 25 mglL) or the control. The 48-hour EC50 value for methylvinyl bis(n-ethylacetamido )silane and Daphnia magna was determined using probit analysis to be 69 mg/L, with 95% confidence intervals of 57 to 88 mglL. The highest concentration producing 0% immobilization was 25 mg/L and the lowest concentration producing 100% immobilization was> 100 mg/L. The No-Observed-Effect Concentration (NOEC) was determined to be 25 mg/L.
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