Registration Dossier
Registration Dossier
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EC number: 214-317-9 | CAS number: 1120-71-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Assessment and expert judgement
- Type of information:
- other: Assessment and expert judgement
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert judgement. Basic data given. Reliable source
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
- Principles of method if other than guideline:
- According to Annex VII "Standard Information Requirements for Substances Manufactured or Imported in Quantities of one Tonne or More" of the "Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC” (as amended) (OJ L 396, 30.12.2006, p 1), 8.2, the "assessment of this endpoint shall comprise the following consecutive steps:
(1) an assessment of the available human and animal data,
(2) an assessment of the acid or alkaline reserve,
(3) in vitro study for eye irritation." - GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2-oxathiolane 2,2-dioxide
- Details on test material:
- not applicable
Constituent 1
Test animals / tissue source
- Species:
- other: not applicable
Test system
- Vehicle:
- other: not applciable
Results and discussion
Any other information on results incl. tables
According to Annex VII "Standard Information Requirements for Substances Manufactured or Imported in Quantities of one Tonne or More" of the "Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC” (as amended) (OJ L 396, 30.12.2006, p 1), 8.2, the assessment of this endpoint comprised the following consecutive steps:
(1) an assessment of the available human and animal data: no reports on adversive effects identified
(2) an assessment of the acid or alkaline reserve: The molecular weight of the substance is 122 g/mole. If the substance is mixed with small amounts of water, due to hydrolyzis, up to aproximately 8 moles/kg of 3-hydroxopropanesulfonic acid may be formed
(3) in vitro study for eye irritation. No in vitro study had to be performed because the available information indicates that a extremely high level of protection is reached.
Corrosive substances are exempted from testing because - in general - they not unawarely in contact with the skin or eye. As the substance is classified as a CMR substance, at least, the same level level of protection is reached and no test is required.
Applicant's summary and conclusion
- Executive summary:
The assessment of this endpoint comprised the following consecutive steps:
(1) an assessment of the available human and animal data: no reports on adversive effects identified
(2) an assessment of the acid or alkaline reserve:The molecular weight of the substance is 122 g/mole. If the substance is mixed with small amounts of water, due to hydrolyzis, up to aproximately 8 moles/kg of3-hydroxopropanesulfonicacidmay be formed
(3) in vitro study for eye irritation. No in vitro study had to be performed because the available information indicates that a extremely high level of protection is reached.
Corrosive substances are exempted from testing because - in general - they not unawarely in contact with the skin or eye. As the substance is classified as a CMR substance, at least, the same level level of protection is reached and no test is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
