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EC number: 421-450-8 | CAS number: 154702-15-5
The objective of this study was to examine the possible sub chronic oral toxicity of the test substance RA 3643 in rats. This substance was administered in the diet, at concentrations of 0, 0.15, 0.5 or 1.5%, to groups of 10 males and 10 female Wistar rats for 13 consecutive weeks.
The ingestion of RA 3643 was well tolerated, as evidenced by the absence of treatment-related changes in the appearance, general condition and behaviour of the animals, their growth, food and water consumption, red blood cell and cloting potential values, total white blood cell counts, clinical chemistry values, renal concentrating ability, composition of the urine, organ weights, gross necropsy findings and histopathological findings.
In comparison with the controls, the mean percentage of neutrophils was higher and that of lymphocytes lower in all groups of female rats given RA 3643.
The differences showed no dose-response relationship and probably resulted from the relatively low neutrophil and high lymphocyte count in the control group.
Most importantly, the differences were not reflected in dose-related or significant changes in the absolute numbers of these cell types and are, therefore, regarded as chance findings, unrelated to treatment.
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