Registration Dossier
Registration Dossier
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EC number: 923-201-3 | CAS number: 1192143-92-2
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment for UMA 121 is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2014).
Persistence
UMA 121 is not considered to be inherently biodegradable based on a study conducted according to OECD 302C (14.8 - 16.6% based on O2 consumption in 28 days). Persistency can therefore not be excluded, and the test substance needs to be considered as very persistent (vP).
Bioaccumulation
The exposure of aquatic organisms to UMA 121 is expected to be minimal, due to the low solubility and high adsorption potential of the substance. In the unlikely event of exposure, uptake of UMA 121 by organisms is considered unlikely, based on the high molecular weight of the UMA homologues (> 500 mg/L). The HPMA constituent is expected to have low bioaccumulation potential, due to its low log Kow value. Based on the available information, UMA 121 is not considered to be bioaccumulative (B) or very bioaccumulative (vB).
Toxicity
A long-term study with Daphnia magna conducted with HPMA, the only potentially bioavailable constituent of UMA 121, resulted to a NOEC (21 d) of 45.2 mg/L. Moreover, UMA 121 is not classified as carcinogenic, mutagenic, or toxic for reproduction according to Regulation (EC) No. 1272/2008 or as T, R48, or Xn, R48 according to Directive 67/548/EEC. Thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are not met and the substance is not considered to meet the T criterion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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