Registration Dossier
Registration Dossier
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EC number: 266-164-2 | CAS number: 66108-95-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted scientifically.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iohexol
- EC Number:
- 266-164-2
- EC Name:
- Iohexol
- Cas Number:
- 66108-95-0
- Molecular formula:
- C19H26I3N3O9
- IUPAC Name:
- 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 370 mg I/ml
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 23 000 - 25 000 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- The acute intravenous toxicity was found to be low, the LD50 at 23 to 25 g I/kg.
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