Registration Dossier
Registration Dossier
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EC number: 266-164-2 | CAS number: 66108-95-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22.10.1984
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize scoring procedure-Acute Toxicology Guidelines, Acute skin and Eye Irritation Tests
- Principles of method if other than guideline:
- Draize scoring procedure-Acute Toxicology Guidelines, Acute skin and Eye Irritation Tests was used. Skin irritancy potential was assessed by applying 0.25 gram Iohexol to intact and abraded skin of New Zealand White rabbits. Less than the standard 0.5 gram of compund was used because of the bulkiness of the compound. Using the Draize scoring procedure, reactions were evaluated at 24 and 72 hours to obtain the primary irritation index. Following application to six areas (three intact and three abraded).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iohexol
- EC Number:
- 266-164-2
- EC Name:
- Iohexol
- Cas Number:
- 66108-95-0
- Molecular formula:
- C19H26I3N3O9
- IUPAC Name:
- 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Preparation of test site:
- abraded
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: Primary Irritation Index
- Value:
- 0
- Remarks on result:
- other:
- Remarks:
- Basis: animal:. Time point: 24 hr. (migrated information)
- Irritation / corrosion parameter:
- other: other: Primary Irritation Index
- Value:
- 0
- Remarks on result:
- other:
- Remarks:
- Basis: animal:. Time point: 72 h. (migrated information)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: other: Draize scoring procedure
- Conclusions:
- The results indicated that Iohexol was not irritating (Primary Irritation Index=0)
- Executive summary:
Skin irritation potential was assessed by applying 0.25 gram Iohexol to intact and abraded skin of New Zealand White rabbits. Less than the standard 0.5 gram of compund was used because of the bulkiness of the compound. Using the Draize scoring procedure, reactions were evaluated at 24 and 72 hours to obtain the primary irritation index. Following application to six areas (three intact and three abraded), the results indicated that Iohexol was non-irritating (Primary Irritation Index=0)
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