Oxirane, 2-methyl-, (2R)-

Toxicity to reproduction

Administrative data

Endpoint:

toxicity to reproduction

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2002

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

propylene oxide

IUPAC Name:

propylene oxide

Constituent 2

Reference substance name:

Methyloxirane

EC Number:

200-879-2

EC Name:

Methyloxirane

Cas Number:

75-56-9

IUPAC Name:

2-methyloxirane

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

The results of the studies described indicated that inhalation exposure to levels of up to 300 ppm over two generations did not produce any adverse effect on reproductive function.