Registration Dossier
Registration Dossier
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EC number: 940-678-3 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study cited by: CIR, 2011. Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics. Final Safety Assessment.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- Caprylyl/Capryl Glucoside
- IUPAC Name:
- Caprylyl/Capryl Glucoside
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Vehicle:
- other: 10% in Hanks’ buffered salt solution
- Details on in vitro test system (if applicable):
- Two human skin samples from each of three donors were used in the study (n=6). The receptor fluid was Krebs ringer’s bicarbonate buffer without HEPES and glucose.
Results and discussion
- Total recovery:
- After 24 h, the mean recovery was 0.52% of caprylyl/capryl glucoside from two tape strips and 0.30% of caprylyl/capryl glucoside in the further 18 tape strips. The mean amount of caprylyl/capryl glucoside removed from the skin (by washing) ranged from 109-145% of the dose applied. The mean absorbed dose of caprylyl/capryl glucoside, as the sum of the amounts found in the viable epidermis, dermis, and receptor medium, was 0.01%.
Applicant's summary and conclusion
- Conclusions:
- The mean absorbed dose of caprylyl/capryl glucoside, as the sum of the amounts found in the viable epidermis, dermis, and receptor medium, was 0.01%.
- Executive summary:
The dermal penetration of caprylyl/capryl glucoside was evaluated in vitro using human skin. The mean absorbed dose, as the sum of the amounts found in the viable epidermis, dermis, and receptor medium, was 0.01%.
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