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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 February 2011 – 27 April 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study has been performed according to OECD and EC guidelines and in compliance with GLP principles.
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
(Official Journal of the European Union no. L142, May 31, 2008)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
other: estimation method
Partition coefficient type:
octanol-water
Analytical method:
other: visual interpretation (octanol solubility), HPLC-UV (water solubility)
Type:
Pow
Partition coefficient:
< 0
Temp.:
20 °C
Remarks on result:
other: neutral pH
Type:
log Pow
Partition coefficient:
< -4.6
Temp.:
20 °C
Remarks on result:
other: neutral pH
Details on results:
n-Octanol solubility
After stirring for 72 hours, undissolved material was observed in the test sample. From this, it was concluded that the n-octanol solubility of E-C104 at 20°C was < 9.6 mg/l.

Water solubility
Water solubility of E-C104 is ≥ 403 g/l (flask method, see section 4.8 for more details).

Partition coefficient
The Pow, calculated as the quotient of the n-octanol- and water solubility, is < 2.4 x 10^-5. This value corresponds with a log Pow value of < - 4.6.
Conclusions:
The estimation method was applied for the determination of the partition coefficient (Pow) of E -C104. The Pow value of the test substance at neutral pH and 20°C was < 2.4 x 10^-5, which corresponds with a log Pow value of < -4.6.

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
-4.6
at the temperature of:
20 °C

Additional information