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EC number: 201-071-2 | CAS number: 77-94-1
The acute dermal toxicity of acetyltri-2 -ethylhexylcitrate (ATEHC) was assessed in a fixed dose procedure in one group of rats comprising 5 males and 5 females according to OECD 402 and EU method B.3 and in compliance with GLP (2000). On the basis of the range finding test, the animals were given a single dermal administration of the test substance at the dose of 2000 mg/kg. The skin was exposed to the test article for 24 h. Clinical observations were carried out at regular intervals during the 14-day observation period. Signs of erythema and oedema were evaluated once daily for 14 days. Body weights were determined immediately before treatment and on days 7 and 14 p.a. Gross pathological examinations were carried out at study termination on all animals and the following results were obtained: No animal died during the 14-day observation period, no abnormal clinical signs, neither signs of erythema nor oedema were observed. There was no influence of the treatment on the body weight development in the male animals during the 14-day observation period. In the female animals, reduced body weight and very slight to slight weight gain were recorded during the 14-day observation period. Gross pathological examinations on day 14 p.a. did not reveal test article-related findings in the rats. Since no deaths were caused in Wistar rats after the dermal treatment with the test substance at a dose of 2000 mg/kg, the LD50 values after 24 h and 14 days were as follows: Male and female > 2000 mg/kg.
It can be assumed that the same applies to tributyl citrate (CAS 77-94-1) as it is a near analogue to the test substance acetyltri-2 -ethylhexylcitrate (ATEHC).
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