Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The BCF was calculated to be 94.7 L/kg (regression-based estimate) and 6.54 L/kg (Arnot-Gobas method), respectively [with BCFBAF v3.01 (EPIWIN software by US-EPA)].

Key value for chemical safety assessment

BCF (aquatic species):
94.7 L/kg ww

Additional information

The prediction for the bioconcentration factor (BCF) of the substance tributyl citrate was done by the computer program BCFBAF v3.01 (EPIWIN software) made available by US-EPA. Furthermore the whole body primary biotransformation rate estimation for fish was calculated with the notation that the bio half-life normalized to 10 g fish at 15 °C. It is possible to predict the apparent metabolism half-life in fish for three different trophic levels (lower, mid and upper). Using the regression-based estimate (traditional method) a BCF of 94.7 L/kg wet-wt (LogBCF = 1.98) was calculated for tributyl citrate. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 6.54 L/kg wet- wt (LogBCF = 0.82) is the result. Both values have been calculated based on an experimental LogPow of 3.5 [low potential for bioaccumulation according to Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP), as value is < 4]. Further, the whole body primary biotransformation rate estimate for fish results in a half-life of 0.00137 days, whereby the bio half-life is normalized to 10 g fish at 15 °C. The rate constant (kM) for 10 g fish is 50/day, whereby the predicted value exceeds theoretical whole body maximum value. This is taken into account to predict the apparent metabolism half-life in fish of tributyl citrate. With the Arnot-Gobas method it is possible to differentiate between three trophic levels. For the lower trophic level the BCF results in 9.263 L/kg wet-wt, for a mid trophic level the result is 8.55 L/kg wet-wt and for the higher trophic level 6.544 L/kg wet-wt. Based on the results, a low potential for bioconcentration is to be expected (according to CLP Regulation 1272/2008 substances with a BCF ≥ 500 have a potential for bioconcentration in aquatic organisms).