Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well performed according to international guidelines but not under GLP conditions

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
yes
Remarks:
Accuracy of the method was determined to be ± 1.0K while the OECD method indicates ±0.5K. This was considered as a minor deviation especially because a melting range was determined.
GLP compliance:
no
Type of method:
other: Differential Scanning Calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of the test item (as cited in the study report): p-METHOXYPROPIOPHENONE
- IUPAC Name of the test item: 1-(4-methoxyphenyl)propan-1-one
- Substance type: monoconstituent
- Physical state: liquid
- Analytical purity: 88.0%
- Purity test date: 2013-01-18
- Lot/batch No.: LABD40 du 17/01/2013
- Expiration date of the lot/batch: January 2015
- Storage condition of test material: +2°C to +8°C, under nitrogen and protected from light

Results and discussion

Melting / freezing point
Melting / freezing pt.:
> 3.6 - < 28.9 °C
Atm. press.:
101 325 Pa
Remarks on result:
other: Maximum of melting : 22 ±1.0°C

Any other information on results incl. tables

- Start of the melting range : between 3.6 and 10.1 ±1.0°C

Applicant's summary and conclusion

Conclusions:
Since the test item is not pure, a melting range is best to characterize it. The three data points describing this range are the following:
- Start of the melting range : between 3.6 and 10.1 ±1.0°C
- Maximum of melting : 22 ±1.0°C
- End of the melting range : 28.9 ±1.0°C
Executive summary:

 The purpose of the study was to determine the melting range of substance p-METHOXYPROPIOPHENONE.

The determination of melting range was performed in accordance with OECD Guideline No 102 “Melting Point/Melting Range” (July 1995). The Differential Scanning Calorimetry (DSC) method was used.

 

Since the test item is not pure, a melting range is best to characterize it. The three data points describing this range are the following:

- Start of the melting range : between 3.6 and 10.1 ±1.0°C

- Maximum of melting : 22 ±1.0°C

- End of the melting range : 28.9 ±1.0°C