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Diss Factsheets
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EC number: 700-945-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 14 January 1985 and 5 February 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study using method similar to stated regulation including information on all key endpoint observations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: U.S. 40 CFR, Section 163.81-1, Federal Register August 22, 1978
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- other: Single dose
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction product of methylenebis(acrylamide) and (O,O)-diisooctyl dithiophosphoric acid
- EC Number:
- 700-945-5
- Molecular formula:
- Complex UVCB substance
- IUPAC Name:
- Reaction product of methylenebis(acrylamide) and (O,O)-diisooctyl dithiophosphoric acid
- Test material form:
- other: Brown viscous liquid
- Details on test material:
- Description: Brown visous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rats weighing 200-300 g were identified by ear punch and housed 5 animals per cage with each cage identifed by a cage card. Husbandry conditions were as follows: themperature 70 to 80 degrees F, relative humidity 55 +/- 25 %, light 12 hour light/dark cycle, diet Wayne Rodent-Blox and tap water ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Single dose followed by a 14-day observation period
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- Animals deprived of food but not water overnight before gavage dosing. Following administration animals were allowed food and water ad libitum for the 14-day observation period. Animals were observed frequently on the day of dosing and then twice a day thereafter (morning and afternoon). Individual weights were recoreded on the day of dosage, and average group weights were recorded on days 7 and 14 post exposure. Gross necropsies were performed on all animals that died or survived until termination at day 14.
- Statistics:
- Not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- No abnormalities were noted.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this study classification of this substance for acute oral toxicity is not required under EU Regulation (EC) No. 1272/2008.
- Executive summary:
Administration of this substance to male and female rats (5/sex/) to 5000 mg/kg did not cause any mortality, body weight changes, clinical observations or gross pathology abnormalities. Based on the results of this study classification of this substance for acute oral toxicity is not required under EU Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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