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Diss Factsheets
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EC number: 700-945-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 29 August 1985 and 12 September 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted using method similar to existing guideline with none or minor deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: U.S. 40 CFR Section 163.81-2 Federal Register August 22, 1978 and subsequently modified in accordance with the revised EPA Pesticide Assessment Guidelines of November 1982
- Deviations:
- not specified
- Principles of method if other than guideline:
- A group of 10 rabbits (5/sex) with health intact skin was used. Approximately 24 hours before testing, the fur was clipped from their back and weighed. A dose of 2000 mg/kg was applied to approximately 10% of the body surface area of each animal. The treated area was covered with a large porous gauze patch and wrapped with an impervious material. Dressings were removed after 24 hours and any excess material was removed as practical using water or an appropriate solvent. Animals were observed for systemic and local signs of toxicity and for mortality frequently during the first day of dosing and twice per day (morning and afternoon) on weekdays and once per day on weekends and holidays through day 14 post exposure. Individual weights were recorded on the day of dosing, weekly thereafter, and prior to sacrifice. Gross pathological evaluation was conducted on all animals.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: Single dose
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction product of methylenebis(acrylamide) and (O,O)-diisooctyl dithiophosphoric acid
- EC Number:
- 700-945-5
- Molecular formula:
- Complex UVCB substance
- IUPAC Name:
- Reaction product of methylenebis(acrylamide) and (O,O)-diisooctyl dithiophosphoric acid
- Test material form:
- other: Gold colored viscous liquid
- Details on test material:
- Description: Gold colored viscous liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals house in stainless steel cages with elevated wire mesh flooring (1/cage), were acclimated 5 days prior to testing and individually identified by an ear tag. Each cage was identified by a cage card. Husbandry conditions were as follows: Temperature 60 to 75 degrees C Relative Humidity 55+/_ 25% Light 12 hours light/dark cycle diet Wayne 15 % Rabbit Ration and tap water ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- A group of 10 rabbits (5/sex) with health intact skin was used. Approximately 24 hours before testing, the fur was clipped from their back and weighed. A dose of 2000 mg/kg was applied to approximately 10% of the body surface area of each animal. The treated area was covered with a large porous gauze patch and wrapped with an impervious material. Dressings were removed after 24 hours and any excess material was removed as practical using water or an appropriate solvent. Animals were observed for systemic and local signs of toxicity and for mortality frequently during the first day of dosing and twice per day (morning and afternoon) on weekdays and once per day on weekends and holidays through day 14 post exposure. Individual weights were recorded on the day of dosing, weekly thereafter, and prior to sacrifice. Gross pathological evaluation was conducted on all animals.
- Duration of exposure:
- 24 hours
- Doses:
- Single dose, 2000 mg/kg
- No. of animals per sex per dose:
- 10 animals (5/sex)
- Control animals:
- no
- Details on study design:
- A group of 10 rabbits (5/sex) with health intact skin was used. Approximately 24 hours before testing, the fur was clipped from their back and weighed. A dose of 2000 mg/kg was applied to approximately 10% of the body surface area of each animal. The treated area was covered with a large porous gauze patch and wrapped with an impervious material. Dressings were removed after 24 hours and any excess material was removed as practical using water or an appropriate solvent. Animals were observed for systemic and local signs of toxicity and for mortality frequently during the first day of dosing and twice per day (morning and afternoon) on weekdays and once per day on weekends and holidays through day 14 post exposure. Individual weights were recorded on the day of dosing, weekly thereafter, and prior to sacrifice. Gross pathological evaluation was conducted on all animals.
- Statistics:
- None, not applicable.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Mild erythema and severe edema was noted in males and females after unrapping at 24 hours. In males no erythema or edema was noted at day 14 termination. In females sight erythema was still noted in 2/5 animals. Diarrhea was observed in one mal (days 11
- Gross pathology:
- None
- Other findings:
- No measurable residual test material was left on the backs after removal following the 24 hour exposure period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on EU CLP Regulation No. 1272/2008 this product is not classified for acute dermal toxicity and there is no evidence of specific organ toxicity.
- Executive summary:
A group of 10 rabbits (5/sex) with health intact skin was used. Approximately 24 hours before testing, the fur was clipped from their back and weighed. A dose of 2000 mg/kg was applied to approximately 10% of the body surface area of each animal. The treated area was covered with a large porous gauze patch and wrapped with an impervious material. Dressings were removed after 24 hours and any excess material was removed as practical using water or an appropriate solvent. Animals were observed for systemic and local signs of toxicity and for mortality frequently during the first day of dosing and twice per day (morning and afternoon) on weekdays and once per day on weekends and holidays through day 14 post exposure. Individual weights were recorded on the day of dosing, weekly thereafter, and prior to sacrifice. Gross pathological evaluation was conducted on all animals.
No mortality or gross abnormalities were noted. Mild erythema and severe edema was noted in males and females after unrapping at 24 hours. In males no erythema or edema was noted at day 14 termination. In females sight erythema was still noted in 2/5 animals. Diarrhea was observed in one mal (days 11 and 12) and one female (day 7). A loss of body weight was noted in two males (days 7 and 14) and one female at day 7 and two females at day 14. No measurable residual test material was left on the backs after removal following the 24 hour exposure period.
Based on EU CLP Regulation No. 1272/2008 this product is not classified for acute dermal toxicity and there is no evidence of specific organ toxicity.
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