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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 429, OPPTS 870.2600
GLP compliance:
yes
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
454-140-6
EC Name:
-
Cas Number:
376608-71-8
Molecular formula:
C9H9F2N*C8H8O3
IUPAC Name:
(1R)-2-(3,4-difluorophenyl)cyclopropan-1-aminium (2R)-2-hydroxy-2-phenylacetate

In vivo test system

Test animals

Species:
mouse
Strain:
CBA
Sex:
female

Study design: in vivo (non-LLNA)

No. of animals per dose:
Number of animals in test group: 4
Number of animals in negative control group: 4

Study design: in vivo (LLNA)

Vehicle:
dimethylformamide

Results and discussion

Any other information on results incl. tables

Comments:
Test substance - results and comments


Concentration of test   DPM/lymph node   Test:control ratio

substance (% w/v)


0 (vehicle control)     425              N/A

0.25                    810              1.91

0.5                    1879              4.42

1                      2625              6.18


Summary of results: C3RO is a skin sensitiser under the
conditions of the test

-----------------------------------------------------------


Positive control substance (hexylcinnamaldehyde) - results
and comments


Concentration of test   DPM/lymph node   Test:control ratio

substance (% w/v)


0 (vehicle control)*    665              N/A

2.5                     921              1.38

5                       938              1.41

10                     2085              3.14


*4:1 acetone in olive oil


Summary of results: A sensitiser under the conditions of the
test.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information