Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)-(1R,2S)-compd. with 2-(3,4-difluorophenyl)cyclopropanamine (1:1)

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Official Journal of the European Communities, L 383 A, Part C.1, Acute toxicity for fish. 29 December 1992.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

454-140-6

EC Name:

-

Cas Number:

376608-71-8

Molecular formula:

C9H9F2N*C8H8O3

IUPAC Name:

(1R)-2-(3,4-difluorophenyl)cyclopropan-1-aminium (2R)-2-hydroxy-2-phenylacetate

Test organisms

Test organisms (species):

other: Rainbow trout (Oncorhynchus mykiss)

Study design

Test type:

semi-static

Test conditions

Hardness:

47.3 mg CaCO3/L

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

85 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 2

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

85 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 3

Duration:

72 h

Dose descriptor:

LC50

Effect conc.:

49 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 4

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

26 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 5

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

120 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 6

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

< 7.5 mg/L