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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
12.01.1983 to 14.01.1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title 16, Section 1500.41.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
[[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
EC Number:
239-931-4
EC Name:
[[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
Cas Number:
15827-60-8
Molecular formula:
C9H28N3O15P5
IUPAC Name:
[(bis{2-[bis(phosphonomethyl)amino]ethyl}amino)methyl]phosphonic acid
Constituent 2
Reference substance name:
[[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetraki sphosphonic acid
IUPAC Name:
[[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetraki sphosphonic acid

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Abraded and intact
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
Approximately 24 hours.
Observation period:
72 hours
Number of animals:
Two

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: The same scores for intact and abraded skin.
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
72 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Necrosis. The same scores for intact and abraded skin.
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Necrosis. The same score for intact and abraded skin at 24 and 72 hours.
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24 and 72 hours
Score:
3
Max. score:
4
Reversibility:
other: Not investigated
Remarks on result:
other: The same score for intact and abraded at 24 and 72 hours.
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24 h
Score:
3
Max. score:
4
Reversibility:
other: Not investigated
Remarks on result:
other: The same score for intact and abraded.
Irritation parameter:
edema score
Basis:
animal #2
Time point:
72 h
Score:
2
Max. score:
4
Reversibility:
other: Not investigated
Remarks on result:
other: The same score for intact and abraded.
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: Individual animal readings were not available.
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: Individual animal readings were not available.
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: Individual animal readings were not available.
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: Individual animal readings were not available.

Any other information on results incl. tables

Well-defined to severe reactions, accompanied by necrotic lesions, were observed in both animals. Due to the severity of the reactions only two animals were exposed to the test substance.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
In a skin irritation study (reliability score 2), which was comparable to an OECD 404 study, Dequest 2060s was corrosive to the skin of two rabbits. Due to the severity of the reaction, additional animals were not tested.