Registration Dossier
Registration Dossier
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EC number: 252-156-6 | CAS number: 34690-00-1
Endpoint summary
Administrative data
Description of key information
There are no skin or eye irritation data available for BHMT-H. Therefore, data are read across from the structural analogue DTPMP-H (CAS 15827-60-8).
See irritation/corrosion endpoint summary for the irritant form of BHMT-H for details on skin and eye irritation data.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 12.01.1983 to 14.01.1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title 16, Section 1500.41.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Abraded and intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- Approximately 24 hours.
- Observation period:
- 72 hours
- Number of animals:
- Two
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: The same scores for intact and abraded skin.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis. The same scores for intact and abraded skin.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis. The same score for intact and abraded skin at 24 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 and 72 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- other: Not investigated
- Remarks on result:
- other: The same score for intact and abraded at 24 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- other: Not investigated
- Remarks on result:
- other: The same score for intact and abraded.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- other: Not investigated
- Remarks on result:
- other: The same score for intact and abraded.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- In a skin irritation study (reliability score 2), which was comparable to an OECD 404 study, Dequest 2060s was corrosive to the skin of two rabbits. Due to the severity of the reaction, additional animals were not tested.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- No data
- Observation period:
- 72 hours
- Number of animals:
- Three
- Remarks on result:
- other: the test substance was concluded to be irritating but not corrosive to rabbit skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Remarks:
- not classified according to CLP Regulation (EC) No 1272/2008
- Conclusions:
- The authors of a letter regarding the skin irritation/corrosion of Dequest 2060s (reliability score 4) summarised the findings of a skin irritation study for which the full study report is not currently available, and concluded that Dequest 2060s is irritating, but not corrosive to the skin of rabbits.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 27.07.1982 to 03.08.1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hylyne Rabbits Ltd, Marston, Northwich, Cheshire
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.83 - 3.00 kg
- Housing: Individually in suspended metal cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Minimum of five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ±4
- Humidity (%): 75-80
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: Within the dates 27.07.1982 to 03.08.1982. - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Applied undiluted
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Back
- % coverage: Not specified.
- Type of wrap if used: Occlusive patch was held in place with two lengths of sleek adhesive strapping.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: four hours
SCORING SYSTEM: Draize - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Very slight erythema was observed in two rabbits at the one hour reading; in one animal this was accompanied by very slight oedema. The reaction had ameliorated in one animal by the 24 hour reading but very slight erythema only persisted in the second rabbit until day 7. One animal did not have any reaction at all.
- Other effects:
- None
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a skin irritation study conducted to GLP and OECD 404 (reliability score 1) Briquest 543-50A (DTPMP acid) was mildly irritating to the skin of two rabbits and not irritating to the skin of one rabbit. The mild irritation was not sufficient to trigger classification.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Limited detail on test substance, methods and animals/conditions. 24-hour exposure duration under occlusive dressing.
- Principles of method if other than guideline:
- Method: other: Insufficient detail to fully assess comparability with OECD guideline.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data - Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml (although the recommended dose of 0.5 ml was achieved for the formulation, this means that the limit dose for the active acid was not attained. The level of irritation of the anhydrous active acid may therefore be underestimated by this study. However, the presence of HCl in the formulation would be predicted to exacerbate the effect seen). - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- Seven days (1, 24, 48, 72, 120 and 168 hours)
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: No data
- % coverage: No data but 1X1 inch square patch used
- Type of wrap if used: Occlusive plastic wrap.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No Data
- Time after start of exposure: No data
SCORING SYSTEM: Draize - Irritation parameter:
- other: Average maximum score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 8
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritant / corrosive response data:
- After one hour there were no skin changes, but by 24 hours there was grade 1 erythema (no oedema) in all three animals. This erythema had disappeared by 48 hours.
- Other effects:
- None
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a skin irritation study (reliability score 2) conducted prior to the adoption of OECD test guidelines and GLP, diethylenetriamine penta(methylene phosphonic acid) was mildly irritating to rabbit skin.
- Executive summary:
In a skin irritation study (reliability score 2) conducted prior to the adoption of OECD test guidelines and GLP, 0.5 ml undiluted 58% w/w solution of diethylenetriamine penta(methylene phosphonic acid) was applied to the clipped, intact skin of three New Zealand white rabbits for 24 hours. A 1x1 inch square patch was used and covered with an occlusive dressing. Skin reactions were scored at 1, 24, 48, 72, 120 and 168 hours using the Draize scoring system. After one hour there were no skin changes, but by 24 hours there was grade 1 erythema (no oedema) in all three animals. This erythema had disappeared by 48 hours. Therefore the test substance was mildly irritating to the skin of rabbits.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: 4a Only an summary report was available for review.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Conducted prior to the adoption of OECD test guidelines.
- Deviations:
- yes
- Remarks:
- Limited detail on test substance, methods and animals/conditions. 24-hour exposure duration under occlusive dressing.
- Principles of method if other than guideline:
- Method: other: Insufficient detail to fully assess comparability with OECD guideline.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data - Type of coverage:
- not specified
- Preparation of test site:
- other: abraded and intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml (although the recommended dose of 0.5 ml was achieved for the formulation, this means that the limit dose for the active acid was not attained. The level of irritation of the anhydrous active acid may therefore be underestimated by this study.However, the presence of HCl in the formulation would be predicted to exacerbate the effect seen). - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- Seven days (4, 24, 48, 72 and 168 hours)
- Number of animals:
- Six
- Details on study design:
- TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: No data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data
SCORING SYSTEM: Draize - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hour
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritant / corrosive response data:
- Very mild (grade 1) erythema at 24 hours in all six animals for intact and abraded skin. This mild reaction had reversed by 48 hours.
- Other effects:
- None reported.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a skin irritation study (reliability score 4), only available as a summary table, and conducted prior to the adoption of the OECD test guidelines, DTPMP-H (Dequest 2060) was only very slightly irritating to rabbit skin.
- Executive summary:
In a skin irritation study (reliability score 4), only available as a summary table, and conducted prior to the adoption of the OECD test guidelines, 0.5 ml undiluted DTPMP-H (Dequest 2060) was applied to the intact and abraded skin of six New Zealand white rabbits. The exposure was stated to be 24 hours, but there was no information on the type of dressing used, or whether the application site was washed. Skin reactions were then graded according to the scoring system of Draize at 4, 24, 48, 72 and 168 hours. Very mild (grade 1) erythema was observed at 24 hours in all six animals for intact and abraded skin. This mild reaction had reversed by 48 hours. DTPMP-H was very slightly irritating to rabbit skin.
Referenceopen allclose all
Well-defined to severe reactions, accompanied by necrotic lesions, were observed in both animals. Due to the severity of the reactions only two animals were exposed to the test substance.
The summary is as follows (no further details included):
"The report creates a slight problem in that two sites per animal were exposed instead of "the test site" referred to in EEC Annex V B4,1.6.3. Analyses of the results can be performed in alternative ways.
1) Each test site analysed separately, whence the test could be regarded as having been carried out on 6 animals.
The scores "per animal" averaged over 1, 24, 48 and 72 hours are:
erythema 1.75, 1.75, 2.0, 1.0, 2.0, 2.0........1.75
oedema 1 , 1 , 1 , 1 , 1 ,1.......1.0
2) The two test sites are averaged for each animal, whence the test is regarded as, having been carried out on 3 animals.
The scores per animal averaged over 1, 24, 48 and 72 hours are:
Erythema: Animal 1, 1.75; Animal 2, 1.5; Animal 3, 2.
Oedema: Animal 1, 1; Animal 2, 1; Animal 3, 1.
ERYTHEMA AND ESCHAR FORMATION
1 hour 1,0,1 (very slight erythema)
24 hours 0,0,1(very slight erythema)
48 hours 0,0,1(very slight erythema)
72 hours 0,0,1(very slight erythema)
OEDEMA FORMATION
1 hour 0,0,1 (very slight oedema)
24, 48, 72 hours 0,0,0
There was no evidence of corrosion in any animal throughout
the test.
Group total = 6, PDII = 6/12 = 0.5
Scored responses were as follows.
1 hour 0,0,0
24 hours 1,1,1 (barely perceptible erythema; no oedema)
48-168 hours 0,0,0
The average maximum score was 1.0 out of a possible 8.
Skin reactions were as follows.
Erythema
Intact:
4 hours 0,0,0,0,0,0
24 hours 1,1,1,1,1,1
48, 72, 168 hours 0,0,0,0,0,0
Abraded:
4 hours 0,0,0,0,0,1
24 hours 1,1,1,1,1,1
48, 72, 168 hours 0,0,0,0,0,0
Oedema formation
In intact and abraded skin throughout the test 0,0,0,0,0,0.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17.01.1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title 16, Section 1500.42.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Buxted rabbit, Buxted, Sussex, England
- Age at study initiation: ca. 14 weeks
- Weight at study initiation: 3.4 kg
- Housing: individually housed in a metal cage with perforated floor
- Diet: Grain Harvester 474 Special rabbit pellets, ad libitum
- Water: tap water ad libitum
- Acclimation period: "the rabbit selected for the study were suitably acclimatised to the laboratory environment"
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19
- Humidity (%): 30-70
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- NA
- Observation period (in vivo):
- One hour after instillation
- Number of animals or in vitro replicates:
- One
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no mention of washing
TOOL USED TO ASSESS SCORE: hand-slit lamp - Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: One hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: Not investigated, animal euthanised after one hour
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: One hour
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- other: Not investigated
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: One hour
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: One hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- other: Not investigated
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not investigated as severe effects seen at 1 hour observation and the animal was euthanised for welfare reasons.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not investigated as severe effects seen at 1 hour observation and the animal was euthanised for welfare reasons.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not investigated as severe effects seen at 1 hour observation and the animal was euthanised for welfare reasons.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not investigated as severe effects seen at 1 hour observation and the animal was euthanised for welfare reasons.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not included as severe effects were seen at 1 hour observation in one animal, which was euthanised for welfare reasons.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- In an eye irritation study (reliability score 2), which was comparable to OECD 405, Dequest 2060s (DTPMP acid) was immediately corrosive to the eye of a rabbit. Additional rabbits were not tested due to the severity of the reaction.
Reference
There was almost instantaneous destruction of the corneal epithelium. This was accompanied by corneal opacification, which over portions of the cornea was severe. Distinct iritis was observed. Well-defined conjunctival swelling with the eye about half closed and necrosis of the nictitating membrane and palpebral and bulbar conjunctivae were observed. The animal was killed one hour after instillation due to the severity of the reactions observed.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are no skin or eye irritation data available for BHMT-H. Therefore, data are read across from the structural analogue DTPMP-H (CAS 15827-60-8).
See irritation/corrosion endpoint summary for the irritant form of BHMT-H for details on skin and eye irritation data.
Justification for classification or non-classification
The neutralised form of BHMT-H is not classified for skin or eye irritation according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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