Registration Dossier
Registration Dossier
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EC number: 907-672-2 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study protocol is poorly documented.
- Justification for type of information:
- This information is in the dossier in support of the RA of the key study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dermal toxicity test with rabbits. Survival and clinical observations were recorded. A gross pathology was conducted.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Acryloid HF-422 (DBPP - polymer)
- IUPAC Name:
- Acryloid HF-422 (DBPP - polymer)
- Reference substance name:
- Dibutyl phenyl phosphate
- EC Number:
- 219-772-7
- EC Name:
- Dibutyl phenyl phosphate
- Cas Number:
- 2528-36-1
- Molecular formula:
- C14H23O4P
- IUPAC Name:
- dibutyl phenyl phosphate
- Details on test material:
- Acryloid HF-422 (70.8% dibutylphenylphosphate and 29.2% n-butylmethacrylate polymer)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- dosage: 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals: 5 males and 5 females
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality:
male: 0/5
female: 0/5 - Clinical signs:
- Six animals had dry and crusty skin in the treatment area. The remaining animals appeared normal.
- Gross pathology:
- Three animals had necrotic spots on their livers. One animal had white sediment in one kidney. Six animals were not remarkable.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
