Registration Dossier
Registration Dossier
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EC number: 907-672-2 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study protocol is poorly documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Primary skin irritation test. Erythema and edema were scored on intact and abraded skin of New Zealand rabbits after 24 and 72 h.
- GLP compliance:
- no
Test material
- Reference substance name:
- Acryloid HF-422 (DBPP - polymer)
- IUPAC Name:
- Acryloid HF-422 (DBPP - polymer)
- Reference substance name:
- Dibutyl phenyl phosphate
- EC Number:
- 219-772-7
- EC Name:
- Dibutyl phenyl phosphate
- Cas Number:
- 2528-36-1
- Molecular formula:
- C14H23O4P
- IUPAC Name:
- dibutyl phenyl phosphate
- Details on test material:
- Acryloid HF-422 (70.8% dibutylphenylphosphate and 29.2% n-butylmethacrylate polymer)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL applied
- Number of animals:
- 6 animals: 3 males and 3 females
- Details on study design:
- SCORING SYSTEM: max. score = 8, erythema + edema
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 72 h
- Score:
- ca. 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
Any other information on results incl. tables
h |
24 |
72 |
||||||
|
ERYTHEMA |
EDEMA |
ERYTHEMA |
EDEMA |
||||
|
intact |
abraded |
intact |
abraded |
intact |
abraded |
intact |
abraded |
1 male |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
2 male |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
3 male |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
4 female |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
5 female |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
6 female |
1 |
1 |
0 |
0 |
1 |
1 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Acryloid HF-422 can be classified as "non-irritant" to the skin.
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