Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-790-3 | CAS number: 593-45-3
A series of studies were conducted to evaluate the teratogenic effects of a C16-C30 light mineral oil in pregnant Sprague-Dawley rats by three separate routes of exposure; inhalation (1000 mg/m3), dermal (2000 mg/kg bw/day), oral gavage (5000 mg/kg bw/day) with exposures on gestation days 6-19. Due to low vapor pressure, the mineral oil was delivered as an aerosol for the inhalation study though aerosol particle size generated was well within the respirable range. There were no observable maternal effects (food consumption, body weight gain) irrespective of route of exposure. No adverse effects on reproductive parameters (implantation number, resorptions, fetal viability) or fetal parameters (body weight, crown-rump length) were observed in any of the studies. There was a clear lack of teratogenicity with regard to abnormal ossification, and adverse effects to external or soft tissue. Spontaneous anomalies were noted in some exposure groups but were not considered exposure related since incidence of such occurrences were similar in the sham-exposed groups. NOAEL for developmental toxicity was ≥ 2000 mg/kg bw/day (dermal), 1000 mg/m3 (inhalation) and 5000 mg/kg bw/day (oral gavage).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again