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nonapotassium 2,4,6-trihydroxy-4-methyl-3,5-dioxa-2,4,6-trisilaheptane-2,6-bis(olate) 2,6,8-trihydroxy-4,6-dimethyl-3,5,7-trioxa-2,4,6,8-tetrasilanonane-2,4,8-tris(olate) 6-hydroxy-2,4,6-trimethyl-1,3,5,2,4,6-trioxatrisilinane-2,4-bis(olate) dihydroxy(methyl)silanolate {[dihydroxy(methyl)silyl]oxy}(hydroxy)methylsilanolate
EC number: 935-877-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 47 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 6
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 280 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the inhalation route is determined on the basis of read-across of the 90-day inhalation NOAEC for trimethoxy(methyl) silane (557 mg/m³). No correction for molecular weight is applied for read-across. The following corrections were made: correction for experimental exposure duration (6 h/d to 8 h/d): 6/8 (ECHA default), correction for respiratory volume (worker): 6.7 m³/day/10 m³/day (ECHA default). Therefore the corrected NOAEC for repeated-dose systemic effects via the inhalation route is: 557*(6 h/ 8 h) *(6.7 m³/day/10 m³/day) =280 mg/m³.
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (sub-chronic to chronic)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- DNEL is based on inhalation study
- AF for other interspecies differences:
- 1
- Justification:
- ECETOC default
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC default
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECETOC default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 47 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 6
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 280 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the inhalation route is determined on the basis of read-across of the 90-day inhalation NOAEC for trimethoxy(methyl) silane (557 mg/m³). No correction for molecular weight is applied for read-across. The following corrections were made: correction for experimental exposure duration (6 h/d to 8 h/d): 6/8 (ECHA default), correction for respiratory volume (worker): 6.7 m³/day/10 m³/day (ECHA default). Therefore the corrected NOAEC for repeated-dose systemic effects via the inhalation route is: 557*(6 h/ 8 h) *(6.7 m³/day/10 m³/day) =280 mg/m³.
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.6 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 158.7 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation from the inhalation NOAEC for trimethoxy(methyl) silane (557 mg/m³) from the 90-day study in rats. No correction for molecular weight is applied for read-across. The following corrections were made: correction for exposure duration: 6 h/8 h (ECHA default for workers), correction for respiratory volume: 0.38 m³/kg (ECHA default, rat, 8 hour). The corrected NOAEL(dermal) is therefore: (557*(6 h/8 h) *0.38 m³/kg) = 158.7 mg/kg/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (sub-chronic to chronic)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default (rat to human)
- AF for other interspecies differences:
- 1
- Justification:
- ECETOC default
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC default
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECETOC default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.6 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 158.7 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation from the inhalation NOAEC for trimethoxy(methyl) silane (557 mg/m³) from the 90-day study in rats. No correction for molecular weight is applied for read-across. The following corrections were made: correction for exposure duration: 6 h/8 h (ECHA default for workers), correction for respiratory volume: 0.38 m³/kg (ECHA default, rat, 8 hour). The corrected NOAEL(dermal) is therefore: (557*(6 h/8 h) *0.38 m³/kg) = 158.7 mg/kg/day
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
Dermal route
The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation from the inhalation NOAEC for trimethoxy(methyl)silane (557 mg/m3) from the 90-day study in rats.
No correction for molecular weight is applied for read-across. The following corrections were made:
Correction for experimental exposure duration: 6 h/8 h (ECHA default for workers)
Correction for respiratory volume: 0.38 m3/kg (ECHA default, rat, 8 hour)
The corrected NOAEL(dermal) is therefore: (557*(6 h/8 h)*0.38 m3/kg) = 158.7 mg/kg bw/day
The following assessment factors were applied to the corrected NOAEL:
Assessment factor for route to route extrapolation (inhalation to dermal): 1 (ECHA default)
Assessment factor for allometric scaling (rat to human): 4 (ECHA default)
Assessment factor for extrapolation of exposure duration (sub-chronic to chronic): 2 (ECHA default)Assessment factor for interspecies differences (systemic): 1 (ECETOC default)
Assessment factor for intraspecies differences (systemic): 3 (ECETOC default)
The overall DNEL (repeated-dose – systemic – dermal) is therefore 158.7/(1*4*2*1*3) =6.6 mg/kg bw/day
Inhalation route
The DNEL for systemic effects via the inhalation route is determined on the basis of read-across of the 90-day inhalation NOAEC for trimethoxy(methyl)silane (557 mg/m3).
No correction for molecular weight is applied for read-across. The following corrections were made:
Correction for experimental exposure duration (6 h/d to 8 h/d): 6/8 (ECHA default)
Correction for respiratory volume (worker): 6.7 m3/day/10 m3/day (ECHA default)
Therefore the corrected NOAEC for repeated-dose local effects via the inhalation route is:
557*(6 h/ 8 h)*(6.7 m3/day/10 m3/day) = 280 mg/m3.
The assessment factors used to determine the DNEL (inhalation) were selected on the following basis:
Assessment factor for extrapolation of exposure duration (sub-chronic to chronic): 2 (ECHA default)
Assessment factor for interspecies differences: 1 (ECECTOC default)
Assessment factor for intraspecies differences: 3 (ECETOC default)
The overall DNEL (repeated-dose – systemic – inhalation) is therefore: 280 mg/m3/(2*1*3)= 47 mg/m3
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 99.5 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the inhalation route is determined on the basis of read-across of the 90-day inhalation NOAEC for trimethoxy(methyl) silane (557 mg/m³). No correction for molecular weight is applied for read-across. The following corrections were made: correction for experimental exposure duration (6 h/d to 24 h/d): 6/24 (ECHA default), correction for number of exposures per week: 5 d/7 d (study data). Therefore the corrected NOAEC for repeated-dose local effects via the inhalation route is: 557*(6 h/ 24 h) *(5 d/7 d) =99.5 mg/m³.
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (sub-chronic to chronic)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- DNEL is based on inhalation study
- AF for other interspecies differences:
- 1
- Justification:
- ECETOC default
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC default
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECETOC default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 99.5 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the inhalation route is determined on the basis of read-across of the 90-day inhalation NOAEC for trimethoxy(methyl) silane (557 mg/m³). No correction for molecular weight is applied for read-across. The following corrections were made: correction for experimental exposure duration (6 h/d to 24 h/d): 6/24 (ECHA default), correction for number of exposures per week: 5 d/7 d (study data). Therefore the corrected NOAEC for repeated-dose local effects via the inhalation route is: 557*(6 h/ 24 h) *(5 d/7 d) =99.5 mg/m³.
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.9 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 40
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 114.4 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation from the inhalation NOAEC for trimethoxy(methyl)silane (557 mg/m³) from the 90-day study in rats. No correction for molecular weight is applied for read-across. The following corrections were made: correction for exposure duration: 6 h/24 h (ECHA default for consumers), correction for number of exposures per week: 5/7 (study data), correction for respiratory volume: 1.15 m³/kg (ECHA default, rat, 24 hour). The corrected NOAEL(dermal) is therefore: (560*(6 h/24 h)*(5/7)*1.15 m³/kg) = 114.4 mg/kg/day.
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (sub-chronic to chronic)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default (rat to human)
- AF for other interspecies differences:
- 1
- Justification:
- ECETOC default
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC default
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECETOC default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.9 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- Overall assessment factor (AF):
- 40
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 114.4 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation from the inhalation NOAEC for trimethoxy(methyl)silane (557 mg/m³) from the 90-day study in rats. No correction for molecular weight is applied for read-across. The following corrections were made: correction for exposure duration: 6 h/24 h (ECHA default for consumers), correction for number of exposures per week: 5/7 (study data), correction for respiratory volume: 1.15 m³/kg (ECHA default, rat, 24 hour). The corrected NOAEL(dermal) is therefore: (560*(6 h/24 h)*(5/7)*1.15 m³/kg) = 114.4 mg/kg/day.
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.42 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 6
- Justification:
- There are insufficient data to determine whether effects are in/dependent of exposure duration, therefore an assessment factor for extrapolation of exposure duration (sub-acute to chronic) has been applied.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default (rat to human)
- AF for other interspecies differences:
- 1
- Justification:
- ECETOC default
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC default
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECETOC default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.42 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- The DNEL for systemic effects via the oral route is determined on the basis of the 28-day oral NOAEL for MTMS (50 mg/kg/day).
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
Dermal route
The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation from the inhalation NOAEC for trimethoxy(methyl)silane (557 mg/m3) from the 90-day study in rats.
No correction for molecular weight is applied for read-across. The following corrections were made:
Correction for exposure duration: 6 h/24 h (ECHA default for consumers)
Correction for number of exposures per week: 5/7 (study data)
Correction for respiratory volume: 1.15 m3/kg (ECHA default, rat, 24 hour)
The corrected NOAEL(dermal) is therefore: (557*(6 h/24 h)*(5/7)*1.15 m3/kg) = 114.4 mg/kg/day
The following assessment factors were applied to the corrected NOAEL:
Assessment factor for route to route extrapolation (inhalation to dermal): 1 (ECHA default)
Assessment factor for allometric scaling (rat to human): 4 (ECHA default)
Assessment factor for extrapolation of exposure duration (sub-chronic to chronic): 2 (ECHA default)Assessment factor for interspecies differences (systemic): 1 (ECETOC default)
Assessment factor for intraspecies differences (systemic): 5 (ECETOC default)
The overall DNEL (repeated-dose – systemic – dermal - consumer) is therefore 114.4/(1*4*2*1*5) = 2.9 mg/kg/day
Oral route
The DNEL for systemic effects via the oral route is determined on the basis of the 28-day oral NOAEL for MTMS (50 mg/kg/day).
The assessment factors used to determine the DNEL (oral) were selected on the following basis:
There are insufficient data to determine whether effects are in/dependent of exposure duration, therefore an assessment factor for extrapolation of exposure duration (sub-acute to chronic) has been applied.
Assessment factor for extrapolation of exposure duration (sub-acute to chronic): 6 (ECHA default)
Assessment factor for allometric scaling (rat to human): 4 (ECHA default)
Assessment factor for interspecies differences: 1 (ECECTOC default)
Assessment factor for intraspecies differences: 5 (ECETOC default)
The overall DNEL (repeated-dose – systemic – oral) is therefore: 50 mg/kg/day/(6*4*1*5)= 0.42 mg/kg/day
Inhalation route
The DNEL for systemic effects via the inhalation route is determined on the basis of read-across of the 90-day inhalation NOAEC for trimethoxy(methyl)silane (557 mg/m3).
No correction for molecular weight is applied for read-across. The following corrections were made:
Correction for experimental exposure duration (6 h/d to 24 h/d): 6/24 (ECHA default)
Correction for number of exposures per week: 5 d/7 d (study data)
Therefore the corrected NOAEC for repeated-dose local effects via the inhalation route is:
557*(6 h/ 24 h)*(5 d/7 d) =99.5 mg/m3.
The assessment factors used to determine the DNEL (inhalation) were selected on the following basis:
Assessment factor for extrapolation of exposure duration (sub-chronic to chronic): 2 (ECHA default)
Assessment factor for interspecies differences: 1 (ECECTOC default)
Assessment factor for intraspecies differences: 5 (ECETOC default)
The overall DNEL (repeated-dose – systemic – inhalation) is therefore: 99.5 mg/m3/(2*1*5)= 10 mg/m3
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