Registration Dossier
Registration Dossier
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EC number: 201-718-9 | CAS number: 87-02-5
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test chemical (authoritative databases, 2018). The study was performed according toOECD Guideline 301 C (Ready Biodegradability: Modified MITI Test. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test chemical was determined to be 6.3, 8.4 and 0% by BOD, TOC removal and UV-Vis parameter in 14 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (2018) prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 14.2% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.183%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2018). If released into the environment, 85.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various experimental key and supporting studies of the test chemical were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study from authoritative databases (2018),biodegradation experiment was conducted for 14 days for evaluating the percentage biodegradability of test chemical. The study was performed according toOECD Guideline 301 C (Ready Biodegradability: Modified MITI Test. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test chemical was determined to be 6.3, 8.4 and 0% by BOD, TOC removal and UV-Vis parameter in 14 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test chemical (GREIM H. et. al., 1994). The study was performed according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test).The percentage degradation of test chemical was determined to be 0% by BOD parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
In a supporting study, biodegradation experiment was conducted for 30 days for evaluating the percentage biodegradability of test chemical (handbook, 2008). The study was performed according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test). Initial test substance conc. used in the study was in the range 3-30 mg/l. The percentage degradation of test chemical was determined to be 0% by ThOD parameter in 30 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
On the basis of above results for test chemical, it can be concluded that the test chemical can be considered to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (2018) prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 14.2% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.183%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2018). If released into the environment, 85.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test chemical can be considered to be not readily biodegradable in nature.
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