Registration Dossier
Registration Dossier
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EC number: 201-718-9 | CAS number: 87-02-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity of test material
- Author:
- Greim et al.
- Year:
- 1 994
- Bibliographic source:
- Chemosphere
- Reference Type:
- other: Authoritative database
- Title:
- Toxicity of test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS Substance Database
- Reference Type:
- other: Authoritative database
- Title:
- Single Dose Oral Toxicity study of the given test chemical in rats
- Author:
- J-CHECK
- Year:
- 2 010
- Bibliographic source:
- J-CHECK , 2010
- Reference Type:
- other: Secondary source
- Title:
- Acute oral toxicity of test chemical
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity test was conducted in ten male wistar rats to assess its LD50 value.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 201-718-9
- EC Name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 87-02-5
- Molecular formula:
- C10H9NO4S
- IUPAC Name:
- 7-amino-4-hydroxynaphthalene-2-sulfonic acid
- Details on test material:
- - IUPAC Name: 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- InChI: 1S/C10H9NO4S/c11-7-1-2-9-6(3-7)4-8(5-10(9)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)
- Smiles: c12c(cc(S(O)(=O)=O)cc1O)cc(N)cc2
- Molecular formula :C10H14O
- Molecular weight :239.25 g/mol
- Substance type:Organic
- Physical state:Solid, powder beige
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160 -180g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 rats /dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for mortality and clinical signs. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at 5000 mg/kg bw in treated animals.
- Clinical signs:
- other: Clinical symptoms were not observed in treated animals.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be >5000 mg/kg bw, when 10 male Wistar rats were treated with the given test chemical via oral route.
- Executive summary:
Acute oral toxicity studywas conducted by using the given test chemical in 10 male Wistar rats at the dose concentration of 5000 mg/kg bw.
The given test chemical was dissolved or suspended in water and administered via oral route.
Animals were observed for mortality and clinical signs for 14 days.No mortality was observed at 5000 mg/kg bw in treated animals. Clinical symptoms were not observed in treated animals.
Hence, the LD50 value was considered to be >5000 mg/kg bw, when 10 male Wistar rats were treated with the given test chemical via oral route.
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