Registration Dossier
Registration Dossier
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EC number: 247-891-4 | CAS number: 26658-19-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- International Program on Chemical Safety - IPCS - Toxicological evaluation of certain food additives
- Author:
- Croda IPCS WHO
- Year:
- 1 982
- Bibliographic source:
- Twenty sixth report of the Joint FAO/WHO Expert Comittee on Food Additives, Geneva, WHO Tech. Rep. Ser. No. 863, 1982
- Report date:
- 1982
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 947
Materials and methods
- Principles of method if other than guideline:
- intraperitoneal injection of test substance in 10 female rats
- GLP compliance:
- no
Test material
- Reference substance name:
- Sorbitan tristearate
- EC Number:
- 247-891-4
- EC Name:
- Sorbitan tristearate
- Cas Number:
- 26658-19-5
- Molecular formula:
- Molecular formula cannot be given as substance is a mixture.
- IUPAC Name:
- (2R)-2-[(2R,3R,4S)-3,4-bis(octadecanoyloxy)oxolan-2-yl]-2-hydroxyethyl octadecanoate; (2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl octadecanoate; (2R)-2-hydroxy-2-[(2R,3R,4S)-3-hydroxy-4-(octadecanoyloxy)oxolan-2-yl]ethyl (9Z)-octadec-9-enoate
- Details on test material:
- - Name of test material (as cited in study report): sorbitan tristearate
- Analytical purity: 50 % aqueous emulsion form
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 125-175 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 10 mL/kg bw (50% aqueous emulsion form)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 48 hours
Results and discussion
- Mortality:
- 2/10 animals died during the first 48 hours after exposure
- Clinical signs:
- Surviving animals did not show any symptoms of toxicity.
- Body weight:
- No data
- Gross pathology:
- No data
Applicant's summary and conclusion
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