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EC number: 247-891-4 | CAS number: 26658-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3h) ≥ 100 mg/L (OECD 209, activated sludge); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Sorbitan tristearate (CAS No. 26658 -19 -5) to microorganisms. The assessment was, therefore, based on studies conducted with the structurally similar category members Sorbitan monoisooctadecanoate (CAS No. 71902-01-7), Sorbitan laurate (CAS No. 1338-39-2) and Sorbitan, octanoate (2:3) (CAS No. 91844-53-0) as part of a read-across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.
The key study conducted with Sorbitan laurate (CAS No. 1338-39-2) was performed as a limit test according to the OECD Guideline 209 and GLP (Desmares-Koopmans, 2010). Activated sludge of a predominantly domestic sewage was exposed to the test concentration of 100 mg/L during 3 hours. No effect on the respiration rate of the activated sludge was observed.
The toxicity of Sorbitan, isooctadecanoate (CAS No. 71902-01-7) and Sorbitan, octanoate (2:3) (CAS No. 91844-53-0) to microorganisms was tested in toxicity controls during ready biodegradation studies (OECD 301 B and OECD 301 F, respectively). If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2012). A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on CO2 evolution (CO2/ThCO2) occurred within 14 days (OECD guideline 301).
For Sorbitan, isooctadecanoate a biodegradation test according to OECD guideline 301 B is available (Clarke, 2012). The test includes a toxicity control, which contains 14.4 mg/L of Sorbitan, isooctadecanoate and 17.1 mg/L of the reference material sodium benzoate. The toxicity control attained 82% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 14.4 mg/L can be used as NOEC.
For Sorbitan, octanoate (2:3) a biodegradation test according to OECD guideline 301 F is available (Ley, 2005). The test includes a toxicity control, which contains 100 mg/L of Sorbitan, octanoate (2:3) and 100 mg/L of the reference material sodium benzoate. The toxicity control attained 73% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 100 mg/L can be used as NOEC.
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