Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-088-3 | CAS number: 7785-84-4
Skin Irritation: Two in vivo studies are available for skin irritation. The study conducted by Younger (1961) is considered to be the key study as the methods used are comparable to modern-day guidelines and the results reported are sufficient for classification and labelling. The study by Bullock (1972) is submitted as a supporting study, primarily because the results are not adequately reported for classification and labelling purposes.Eye irritation: Two in vivo studies are available for eye irritation and are provided as a weight of evidence to negate the need for further in vivo studies on the grounds that further testing in animals is not scientifically justified and in vitro testing is not considered to be suitable for classification unless the substance is corrosive (Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures). Trisodium trimetaphosphate is not considered to be corrosive and therefore further testing has not been conducted.
Table 1 - Skin irritation in rabbits - sample applied as a finely ground powder
Numerical evaluation at the end of
A score of 0 is sufficient to classify the test material as non-irritating in powder form.
Table 2 - Skin irritation in rabbits - sample applied as a 20.0% aqueous solution
A score of 1(/8) is sufficient to classify the test material as a slight irritant in liquid form.
Table 1 : In vivo eye irritation results in rabbits for sodium trimetaphosphate (2 animals)
Time point (hrs)
Table 2 : In vivo eye irritation results (total scores) in rabbits for sodium trimetaphosphate
Number Responding/Mean Score for 6 Rabbits
Table 1 - Eye irritation in rabbits after application of sodium trimetaphosphate.
The compound was classed as a mild eye irritant under the Draize system (Not sufficient for classification under Regulation (EC) No. 1272/2008 (EU CLP).
Justification for selection of skin irritation / corrosion endpoint: This study has been selected as the key study in accordance with Regulation (EC) No. 1907/2006 (REACH) because the results are sufficient in order to derive a reliable conclusion on classification and labelling in accordance with Regulation (EC) No. 1272/2008 (EU CLP). No effects are noted. Justification for selection of eye irritation endpoint: No study is selected as a weight of evidence approach in accordance with Annex XI, section 1.2. of Regulation (EC) No. 1907/2006 (REACH) has been used to address the endpoint 'eye irritation' and no effects were noted.
Skin irritation: The data available to assess the skin irritation potential of trisodium trimetaphosphate concludes that the substance is not classified in accordance with Regulation (EC) No. 1272/2008 (EU CLP). It is not considered scientifically justified on ethical grounds to repeat in vivo studies for this endpoint as the data provided is sufficient.
Eye irritation: The data available to assess the eye irritation potential of trisodium trimetaphosphate concludes that the substance is not classified in accordance with Regulation (EC) No. 1272/2008 (EU CLP). It is not considered scientifically justified on ethical grounds to repeat in vivo studies for this endpoint as the data provided is sufficient.
Respiratory irritation: There are no data available (workplace observations or studies) to suggest that trisodium trimetaphosphate is a respiratory irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again