Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-866-0 | CAS number: 498-66-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: current study according to OECD protocol and under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 8,9,10-trinorborn-2-ene
- EC Number:
- 207-866-0
- EC Name:
- 8,9,10-trinorborn-2-ene
- Cas Number:
- 498-66-8
- Molecular formula:
- C7H10
- IUPAC Name:
- Bicyclo-[2.2.1]-hept-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 2-Norbornene
- Physical state: off-white solid
- Lot/batch No.: 119702
- Expiration date of the lot/batch: Feb. 2013
- date received: Oct, 1 2009
- Storage condition of test material: Fapprox. 4°C in the dark under Nitrogen
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- Source: Harlan Laboratories UK Ltd; Bicester, Oxon, UK
Age at start of study: 8-12 weeks
Weight at start of study: 15 - 23 g
Housing: individually in susended solid floor polypropylene cages
Diet and Water:ad libitum
temperature: 19 - 25°C
humidity: 30 - 70%
acclimitisation period: >= 5d
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 50%; 25%; 10% + control (vehicle)
- No. of animals per dose:
- 4
- Details on study design:
- Range Finding Test:
compund solubility: soluble in acetone/olive oil 4:1 at 50% (w/w).
no signs of irritation or systemic toxicity at 50% (w/w) during observation period (day 1-6 post dose)
Main Study
Days 1-3: 25 µl of test solution were applied each day to the dorsal surface of each ear. The test material was applied with an automatic pipette and spread over the dorsal surface of the ear using the tip of the pipette. Each concentration group and the control group were treated in the same manner.
Days 4 and 5: no treatment
Day 6: All mice were injected with 250 µl phosphate buffered saline containing 3H-methyl thymidine, giving a total of 20 µCi to each mouse.
5 hours after application the animal were killed.
The lymph nodes of ech group were pooled for further treatment. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: see table 1 below for test substance. In a separate experiment for the positive controol, the stimulation index for 15%(v/v) of hexyl cinnamic aldehyde in acetone/olive oil 4:1 was determined. The S.I. was 3.70.
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: see table 1 below
Any other information on results incl. tables
Table 1
concentration | dpm | dpm/node | S.I. | Result | |
vehicle (acetion/olive oil 4:1) | 16706,59 | 2088,32 | n.a. | n.a. | |
10% | 10183,23 | 1272,9 | 0,61 | negative | |
25% | 8534,56 | 1066,81 | 0,51 | negative | |
50% | 16334,21 | 2041,78 | 0,98 | negative |
dpm: disintegrations per minute
S.I: Stimulation Index
n.a. not applicable
clinical observations and mortality: There were no death and no signs of systemic toxicity noted in the test or control group animals during the test. Body weight changes of the test anmal between day 1 and 6 were comparable to those observed with the control group animals during the same period.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- the test-substance is a non-sensitizer under the conditions of the test.
- Executive summary:
the test substance was applied in concentrations of 10, 25 and 50%. The observed S.I. were 0,61, 0,51 and 0,98 for each of the concentrations. The positive control showed an S.I. of 3.7. A S.I. of 3 is considered as the threshold for a positive response.
Conclusion: The test substance is non-sensitizing under test conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.