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EC number: 953-797-0 | CAS number: 210300-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-hydroxy-4-methoxypyridine-2-carboxylic acid
- Cas Number:
- 210300-09-7
- Molecular formula:
- C7H7NO4
- IUPAC Name:
- 3-hydroxy-4-methoxypyridine-2-carboxylic acid
Constituent 1
- Specific details on test material used for the study:
- Substance name: X696476
Lot #: XS9-109113-80 (TSN300901)
Purity: 100%
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- other: Static-renewal
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 150 mg CaCO3/L
- Test temperature:
- 19.3 to 20.9°C
- pH:
- 8.3 to 8.5
- Dissolved oxygen:
- Dissolved Oxygen (new): 8.1 to 9.0 mg/L (95 to 103% sat.)
Dissolved Oxygen (old): 8.5 to 9.1 mg/L (96 to 105% sat.) - Salinity:
- Alkalinity: 160 mg CaCO3/L
- Conductivity:
- 349 μS
- Nominal and measured concentrations:
- Nominal: 0 (control), 0.63, 1.3, 2.5, 5.0, and 10 mg/L
Mean measured:
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 9.53 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: immobility
- Remarks on result:
- other: highest concentration tested
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 9.53 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: immobility and sublethal effects
- Remarks on result:
- other: highest concentration tested
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 48 h EC50 (Daphnia): >9.53 mg/L
48 h NOEC (Daphnia): 9.53 mg/L - Executive summary:
A definitive test was performed at nominal concentrations 0 (control), 0.63, 1.3, 2.5, 5.0, and 10 mg/L. Five neonates (<24-hours old) were added to each of four test chambers per treatment at the start of the test. The daphnids were observed for immobility and sublethal effects at approximately 24 and 48 hours after test initiation.
Total hardness, total alkalinity, and conductivity were measured in the dilution water at test initiation. Temperature, dissolved oxygen concentration, and pH were measured in all treatment replicates daily. A thermistor probe was located in a surrogate test chamber to continuously record temperature.
All test acceptability criteria were met for this study. Immobilization among control daphnids was 0%, which is below the acceptability limit of 10% as stated in the protocol and the OECD 202 test guideline. The dissolved oxygen concentration at the end of the test was ≥ 8.5 mg/L in control and test substance treatments, higher than the acceptability minimum of 3 mg/L. This study is classified as acceptable and satisfies the guideline requirement for an acute toxicity test with Daphnia magna.
Based on arithmetic and geometric mean measured concentrations, the 24-hour and 48-hour EC50 values were >9.53 and >9.50 mg/L, respectively, the highest concentration tested. The 48 hour NOEC, based on arithmetic and geometric mean measured concentrations, was 9.53 and 9.50 mg/L, respectively, based on the absence of statistically significant immobility and sublethal effects at this, and all lower test substance concentrations.
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