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Diss Factsheets
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EC number: 214-170-0 | CAS number: 1107-00-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The Acute Oral Toxicity potential of 6FDA was evaluated by obtaining predictions using T.E.S.T “Oral LD50 rat” QSAR model and ProTox “Oral Acute Toxicity (Rodent)” QSAR model. The predictions were obtained using the nearest neighbour method based on the structural similarity between analogue substances with known LD50 and the target chemical 6FDA.
The T.E.S.T. model predicted an LD50 (rat) for 6FDA of 1637.93 mg/kg bw and the ProTox model estimated an LD50 (rodent) of 1900 mg/kg bw for 6FDA. The values ranged from 300 to 2000 mg/kg bw, so according to the criteria established in the CLP Regulation, 6FDA can be expected to be classified as Acute Toxicity Category 4.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Expert Assessment
- Adequacy of study:
- weight of evidence
- Study period:
- March 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Based on structural alerts and QSAR models
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Predictions for Acute Oral Toxicity endpoint were performed for 6FDA using T.E.S.T and ProTox softwares. The consensus and hierarchical clustering methods in T.E.S.T could not give reliable
predictions, therefore the nearest neighbour method based on structure similarity between analogue substances and the target chemical was used. - GLP compliance:
- no
- Test type:
- other: Expert Assessment based on structural alerts and QSAR models
- Limit test:
- no
- Dose descriptor:
- LD50
- Effect level:
- 1 900 mg/kg bw
- Based on:
- other: ProTox model
- Remarks on result:
- other: Predicition
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 1 637.93 mg/kg bw
- Based on:
- other: T.E.S.T. model
- Remarks on result:
- other: Prediction
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- 6FDA can be expected to be classified as Acute Toxicity Category 4.
- Executive summary:
The Acute Oral Toxicity potential of 6FDA was evaluated by obtaining predictions using T.E.S.T “Oral LD50 rat” QSAR model and ProTox “Oral Acute Toxicity (Rodent)” QSAR model. The predictions were obtained using the nearest neighbour method based on the structural similarity between analogue substances with known LD50 and the target chemical 6FDA.
The T.E.S.T. model predicted an LD50 (rat) for 6-FDA of 1637.93 mg/kg bw and the ProTox model estimated an LD50 (rodent) of 1900 mg/kg bw for 6-FDA. The values ranged from 300 to 2000 mg/kg bw, so according to the criteria established in the CLP Regulation, 6-FDA can be expected to be classified as Acute Toxicity Category 4.
Reference
The T.E.S.T. model predicted an LD50 (rat) for 6FDA of 1637.93 mg/kg bw and the ProTox
model estimated an LD50 (rodent) of 1900 mg/kg bw for 6FDA. The values ranged from 300
to 2000 mg/kg bw, so according to the criteria established in the CLP Regulation, 6FDA can
be expected to be classified as Acute Toxicity Category 4.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 637.93 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.