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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

The short-term toxicity of 6FDA to aquatic invertebrates was determined during a GLP-compliant study performed according to OECD Guideline 202.

Since the substance was poorly water soluble, Water Accomodated Fractions (WAF) were prepared.  Results are expressed on the initial loading of the test substance required to produce effects.

The species was Daphnia magna.

A range finding test was performed to determine the concentrations to be used in the definitive test.  As a result, concentrations of 100, 180, 320, 560, 1000, 1800, 3200, 5600 and 10,000 mg/L were used during the definitive test.

The 48-hour EC50 was 29.9 mg/L and the 48-hour NOEC was 10 mg/L.


A short-term toxicity study to determine the aquatic toxicity of 6FDA to freshwater unicellular algae (pseudokirchneriella subcapitata) was determined by a GLP compliant study performed in accordance with the OECD 201 test guideline.

In order to determine the concentrations to be used in the definitive test, a range finding study was performed over 72 hours to determine the appropriate concentrations at which growth rate effects were observed.  6FDA was characterised as poorly water soluble and was therefore prepared by water accomodated fractions (WAF). 

The concentration range used in the definitive test was 1000, 1800, 3200, 5600 and 10000 mg/L.

The 72-hour EC50 for 6FDA was 4400 mg/L

Additional information