1,4,10,13-pentaoxacyclopentadecane

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Thirteen Cationic Ionophores: Their Acute Toxicity, Neurobehavioral and Membrane Effects

Author:

S. C. Gad, C. Reilly, K. Siino, F. A. Gavigan & G. Witz

Year:

2008

Bibliographic source:

DRUG AND CHEMICAL TOXICOLOGY, 8( 6 ) , 451-468 (1985)

Materials and methods

Principles of method if other than guideline:

15-Crown-5 was applied to eyes of rabbits and then scored by the Draize procedure at 1, 2, 3, 4, 7 and 10 days post installation.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,4,10,13-pentaoxacyclopentadecane

EC Number:

251-379-6

EC Name:

1,4,10,13-pentaoxacyclopentadecane

Cas Number:

33100-27-5

Molecular formula:

C10H20O5

IUPAC Name:

1,4,7,10,13-pentaoxacyclopentadecane

Test animals / tissue source

Species:

rabbit

Test system

Amount / concentration applied:

0.01 mL

Results and discussion

In vivo

Results

Irritation parameter:

other: Eye irritation grade

Basis:

mean

Time point:

other: 1, 2, 3, 4, 7 and 10 days

Remarks on result:

probability of moderate irritation

Applicant's summary and conclusion

Conclusions:

The test substance is considered to cause Moderate eye irritation