Registration Dossier

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Hazard for air

Hazard for terrestrial organisms

Hazard for predators

Additional information

Aquatic toxicity:

Three acute experimental studies and two QSAR predictions are available to assess the aquatic toxicity of the registered substance.

The two experimental studies, performed on aquatic invertebrates Daphnia magna and the algae Desmodesmus subspicatus respectively, were not considered reliable due to major methodological deficiencies and/or insufficient information provided on the methodology used. Therefore, QSAR predictions for these endpoints were performed using iSafeRat® High-Accuracy-Quantitative Structure-Activity Relationship (KREATIS, 2019). Toxic effects were predicted on aquatic invertebrates and algae in acute conditions. For daphnids, the 48h-EC50 value was predicted at 0.92 mg/L. For algae, the 72h-ErC50 value was predicted at 2.5 mg/L.

Finally, the experimental study performed on fish Danio rerio was considered reliable (with restrictions). The 96h-LC50 value was determined at 1.9 mg/L, based on initial measured concentrations.

Environmental fate and pathways:

The registered substance is not readily biodegradable (1% biodegradation after 28 days in the OECD 301F key study, 4% biodegradation after 60 days). Thus, in the absence of other studies, the registered substance can be considered potentially Persistent (P) or very Persistent (vP) in the environment. In addition, with a log Kow value at 5.0, the registered substance is considered to be bioaccumulative according to CLP (> 4.0) and potentially B/vB following PBT criteria (> 4.5).

Conclusion on classification

No harmonised classification is available.


 


Data available:


- Lowest E(L)C50 value < 1 mg/L, more precisely between 0.1 and 1 mg/L (M-factor = 1);


- Not rapidly degradable;


- log Kow > 4.


 


Classification according to the Annex I of the Regulation (EC) No 1272/2008 (CLP) and GHS Regulation: The registered substance is classified as Aquatic Acute 1 (M-factor = 1) and Aquatic Chronic 1 for the environment.