Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

Administrative data

Assessed Substance

Assessed substance:
substance itself
Reference substance name:
IUPAC name:
ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate
CAS number:
L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester
Molecular formula:
Molecular weight:
ca. 387.44
L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester
Type of composition:
boundary composition of the substance
State / form:
solid: particulate/powder
Reference substance:
L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester
PBT status of the assessed substance:
the substance is not PBT / vPvB

Results of detailed PBT / vPvB assessment


Evidence of non-P / non-vP properties
Screening criteria
Criteria based on Annex XIII of REACH
Conclusion on P / vP properties:
not P/vP
Due to the degradation (17% in 10 d) the substance is classified as not readily biodegradable. The classification for "not ultimately biodegradable within 28 days” (19% in 28 d) is also not met.


Evidence of non-B / non-vB properties
Screening criteria
Not B and not vB based on: Log Kow ≤ 4.5
The log POW of the substance is 0.9
Criteria based on Annex XIII of REACH
Conclusion on B / vB properties:
not B/vB


Evidence of non-T properties
Criteria based on Annex XIII of REACH
Not T based on:
EC10 or NOEC ≥ 0.01 mg/L for marine / freshwater organisms (long-term toxicity):
all Values are above this threshold
and substance is not classified as carcinogenic (category 1 or 2), mutagenic (category 1 or 2), or toxic for reproduction (category 1, 2 or 3) according to Directive 67/548/EEC or carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008:
this does apply
and no other evidence of chronic toxicity, as identified by the classifications T, R48 or Xn, R48 according to Directive 67/548/EEC or specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to Regulation EC No 1272/2008:
this does apply
Evidence of T properties
Conclusion on T properties:
not T