1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 Jul - 19 Aug 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Test guideline 3

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)

Test guideline 4

Qualifier:

equivalent or similar to guideline

Guideline:

other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction

GLP compliance:

yes (incl. QA statement)

Remarks:

Hess. Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany

Type of method:

Laser scattering/diffraction

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone

EC Number:

855-228-0

Cas Number:

4497-59-0

Molecular formula:

C14 H19 N O

IUPAC Name:

1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone

Results and discussion

Particle size

Particle size 1

Percentile:

D10

Mean:

20 µm

Remarks on result:

other: standard deviation not reported. The value is measured in the fraction after sieving with mesh size of 1000 µm (98.7% of the test item passed the sieve).)

Particle size 2

Percentile:

D50

Mean:

198.6 µm

Remarks on result:

other: standard deviation not reported. The value is measured in the fraction after sieving with mesh size of 1000 µm (98.7% of the test item passed the sieve).)

Particle size 3

Percentile:

D90

Mean:

633.1 µm

Remarks on result:

other: standard deviation not reported. The value is measured in the fraction after sieving with mesh size of 1000 µm (98.7% of the test item passed the sieve).)

Any other information on results incl. tables

Results:
The test item consisted of agglomerated particles which appeared partially translucent and were irregularly formed.

The test item was sieved with a mesh size of 1000 µm. 98.7 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction. 

The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bar_g). After passing the analyser beam the sample was collected in a vacuum cleaner.

After adjusting the laser, measuring the background and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 8 s. Median values were calculated from unrounded values.

Individual results:
The median particle size L₅₀ (D (v, 0.5): 50 % of particle volume with lower particle diameter) deduced from these distributions were:
L₅₀: 200.2 μm (1st test series), 197.1 μm (2nd test series)
The average of the median particle size L₅₀ was: L₅₀ = 198.6 µm

The particle size L₁₀ (D (v, 0.1): 10 % of particle volume with lower particle diameter) deduced from these distributions were:
L₁₀: 20.2 μm (1st test series), 19.7 μm (2nd test series)
The average of the particle size L₁₀ was: L₁₀ = 20.0 µm

The particle size L₉₀ (D (v, 0.9): 90 % of particle volume with lower particle diameter) deduced from these distributions were:
L₉₀: 635.8 μm (1st test series), 630.4 μm (2nd test series)
The average of the particle size L₉₀ was: L₉₀ = 633.1 µm

The maxima were observed at approximately 40 µm and approximately 300-400 µm. Additionally a shoulder was observed at approximately 5 µm.