3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) and 3,5-Heptanedione-1,7-bis(4-hydroxyphenyl) and 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl)

Eye irritation

Administrative data

Endpoint:

eye irritation, other

Type of information:

experimental study

Adequacy of study:

key study

Study period:

44 Days

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

EC Number:

900-021-3

Molecular formula:

3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) :C20 H22O5, 3,5-Heptanedione-1,7 -bis(4-hydroxyphenyl) : C19H20O4, 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl) : C21H24O6

IUPAC Name:

1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Test material form:

solid: crystalline

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

water

Controls:

yes

Duration of treatment / exposure:

24h

Observation period (in vivo):

48h

Number of animals or in vitro replicates:

3

Results and discussion

In vitro

Results

Irritation parameter:

in vitro irritation score

Vehicle controls validity:

valid

Negative controls validity:

not specified

Positive controls validity:

not specified

Remarks on result:

no indication of irritation

Applicant's summary and conclusion

Interpretation of results:

Category 2B (mildly irritating to eyes) based on GHS criteria

Conclusions:

The test material falls under "Non Irritating" Category of UN GHS Classification.