3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) and 3,5-Heptanedione-1,7-bis(4-hydroxyphenyl) and 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl)

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 Days

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 471 (Bacterial Reverse Mutation Assay)

Deviations:

no

GLP compliance:

yes

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

EC Number:

900-021-3

Molecular formula:

3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) :C20 H22O5, 3,5-Heptanedione-1,7 -bis(4-hydroxyphenyl) : C19H20O4, 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl) : C21H24O6

IUPAC Name:

1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Test material form:

solid: crystalline

Results and discussion

Test results

Key result

Species / strain:

S. typhimurium TA 1535

Remarks:

S. typhimurium TA 100

Metabolic activation:

without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

no cytotoxicity

Vehicle controls validity:

valid

Untreated negative controls validity:

valid

True negative controls validity:

valid

Positive controls validity:

valid

Remarks on result:

other: Non Mutagenic

Applicant's summary and conclusion

Conclusions:

Bacterial Reverse Mutation Test in Salmonella typhimurium Tester strains for substance confirms it is non-mutagenic .
The study is performed in compliance with OECD guidelines No.471.