Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-731-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-04-11 to 2016-10-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Colour and appearance: Colourless solid
- Batch: C14-193
- Purity: 100% (w/w)
- Expiry date: 15 Dec 2016
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: ambient: (+5 to +30 °C), dark, dry - Key result
- Water solubility:
- <= 2 925 µg/L
- Conc. based on:
- other: Lutetium
- Incubation duration:
- 864 h
- Temp.:
- 20 °C
- pH:
- 6.14
- Key result
- Water solubility:
- <= 115 µg/L
- Conc. based on:
- other: Yttrium
- Incubation duration:
- 864 h
- Temp.:
- 20 °C
- pH:
- 6.14
- Key result
- Water solubility:
- <= 0.823 µg/L
- Conc. based on:
- other: Cerium
- Incubation duration:
- 864 h
- Temp.:
- 20 °C
- pH:
- 6.14
- Key result
- Water solubility:
- <= 0.218 mg/L
- Conc. based on:
- other: Silicon
- Incubation duration:
- 864 h
- Temp.:
- 20 °C
- pH:
- 6.14
- Details on results:
- The results for lutetium differ between the two bottles due to inhomogeneity of the test item. No mean solubility was calculated but the results of the two bottles were reported separately. The maximum solubility for each bottle which was determined is reported as result of the study. For silicon, cerium and yttrium the maximum mean is reported as result of the study.
- Conclusions:
- The water solubility of the test item was determined in ultra-pure water at 20 °C:
Lutetium: ≤ 2925 µg/L / 2052 µg/L
Yttrium: ≤ 115 µg/L
Cerium: ≤ 0.823 µg/L
Silicon: ≤ 0.218 mg/L - Executive summary:
The water solubility of the test item was determined in ultra-pure water at 20 °C in adaption to EC method A.6 and OECD guideline 105 by using the flask method. The results for lutetium differ between the two bottles due to inhomogeneity of the test item. No mean solubility was calculated but the results of the two bottles were reported separately. For silicon, cerium and yttrium the maximum mean is reported as study result:
Lutetium: ≤ 2925 µg/L / 2052 µg/L
Yttrium: ≤ 115 µg/L
Cerium: ≤ 0.823 µg/L
Silicon: ≤ 0.218 mg/L
Reference
The results of the preliminary test are presented in Table 1.
Table 1: Preliminary test in ultra-pure water at 20 °C
Test item [mg] | Added volume of water [mL] | Time of shaking [h] | Remarks | Approx.solubility [g/L] |
10.9 | 1000 | 168 | undissolved | < 0.0109 |
The main test was performed in carbon dioxide saturated ultra-pure water. Tables 2 -5 show the results of the samples.
Table 2: Time course of the water solubility of lutetium in the test item at 20 °C and pH 5.97
Time [h] | Sample no. | Determined concentration of lutetium [µg/L] | Mean concentration of lutetium [µg/L] | pH |
24 | 1 2 |
333 298 |
316 | 5.95 |
192 | 1 2 |
977 1003 |
990 | 5.95 |
312 | 1 2 |
1181 1158 |
1170 | 5.92 |
384 | 1 2 |
1330 1434 |
1382 | 5.98 |
552 | 1 2 |
1536 1485 |
1511 | 5.93 |
696 | 1 2 |
1629 1575 |
1602 | 5.95 |
864 | 1 2 |
2925* 2052* |
2489 | 6.14 |
Mean: | 5.97 |
* As the results of the individual determinations differ that much, not the mean will be reported, but the individual results.
Table 3: Time course of water solubility of cerium in the test item at 20 °C and pH 5.97
Time [h] | Sample no. | Determined concentration of cerium [µg/L] | Mean concentration of cerium [µg/L] | pH |
24 | 1 2 |
0.149 0.176 |
0.163 | 5.95 |
192 | 1 2 |
0.469 0.493 |
0.481 | 5.95 |
312 | 1 2 |
0.566 0.578 |
0.572 | 5.92 |
384 | 1 2 |
0.639 0.661 |
0.650 | 5.98 |
552 | 1 2 |
0.699 0.702 |
0.701 | 5.93 |
696 | 1 2 |
0.800 0.758 |
0.779 | 5.95 |
864 | 1 2 |
0.834 0.812 |
0.823 | 6.14 |
Mean: | 5.97 |
Table 4: Time course of the water solubility of yttrium in the test item at 20 °C and pH 5.97
Time [h] | Sample no. | Determined concentration of yttrium [µg/L] | Mean concentration of yttrium [µg/L] | pH |
24 | 1 2 |
23.4 25.8 |
24.6 | 5.95 |
192 | 1 2 |
65.5 68.6 |
67.1 | 5.95 |
312 | 1 2 |
80.1 85.5 |
82.8 | 5.92 |
384 | 1 2 |
91.6 93.9 |
92.8 | 5.98 |
552 | 1 2 |
103 99.5 |
101 | 5.93 |
696 | 1 2 |
114 104 |
109 | 5.95 |
864 | 1 2 |
117 113 |
115 | 6.14 |
Mean: | 5.97 |
Table 5: Time course of the water solubility of silicon in the test item at 20 °C and pH 5.97
Time [h] | Sample no. | Determined concentration of silicon [mg/L] | Mean concentration of silicon [mg/L] | pH |
24 | 1 2 |
n.d. n.d. |
n.d. | 5.95 |
192 | 1 2 |
0.134 0.140 |
0.137 | 5.95 |
312 | 1 2 |
0.156 0.160 |
0.158 | 5.92 |
384 | 1 2 |
0.170 0.161 |
0.166 | 5.98 |
552 | 1 2 |
0.205 0.203 |
0.204 | 5.93 |
696 | 1 2 |
0.210 0.205 |
0.208 | 5.95 |
864 | 1 2 |
0.215 0.221 |
0.218 | 6.14 |
Mean: | 5.97 |
n.d. - not detected
According to OECD Guideline 105 it is considered to use the column elution method for water solubilities below 10-2 g/L. On the other hand the idea of the column elution method is to increase the surface of the test item to improve the contact with the eluent. This is mostly applicable for organic compounds. In case of inorganic metal powder there is no increasing of the surface by using the column elution method, so the flask method was used.
Description of key information
The water solubility of the test item was determined in ultra-pure water at 20 °C in adaption to EC method A.6 and OECD guideline 105 by using the flask method. The results for lutetium differ between the two bottles due to inhomogeneity of the test item. No mean solubility was calculated but the results of the two bottles were reported separately. For silicon, cerium and yttrium the maximum mean is reported as study result:
Lutetium: ≤ 2925 µg/L / 2052 µg/L
Yttrium: ≤ 115 µg/L
Cerium: ≤ 0.823 µg/L
Silicon: ≤ 0.218 mg/L
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
