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EC number: 811-285-3 | CAS number: 1637294-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 May, 2015 to 07 October, 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- July, 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- NYMPHEAL (GR-88-0778) :
Lot No. : Batch 6
Purity : 99.1% (sum of isomers)
Date of Expiry : 29 March, 2017 - Analytical monitoring:
- yes
- Remarks:
- GC-MS
- Details on sampling:
- Water samples were taken, extracted and analysed at the Following time-points for exposure concentrations C1 to C5 :
- Fresh exposure medium : 0 hrs and at all subsequent renewals (24hrs, 48hrs, 72hrs);
- Aged exposure medium : 24 hrs, 48 hrs, 72 hrs and 96 hrs
Samples of the Control and the Solvent Control were sampled, extracted and analysed at : Time 0 (fresh) and aged medium at 96 hours.
- Vehicle:
- yes
- Remarks:
- Acetone, at maximum concentration of 0.1 mL/L.
- Details on test solutions:
- Following a Range-Finding study, the Following Nominal test concentrations were chosen for the definitive study :
C1 0.48 mg/L
C2 0.86 mg/L
C3 1.54 mg/L
C4 2.78 mg/L
C5 5.00 mg/L
The exposure solutions were prepared using standards prepared in Acetone as a vehicle. Since NYMPHEAL is a primary aldehyde, and, therefore, susceptible to undergo rapid oxidation, it was decided to avoid long, drawn-out exposure medium preparation techniques (e.g. slow-stirring to obtain water saturated fraction).
A blank Control and Solvent Control were also performed. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Danio rerio in-house culture
Spawning Date : Nov. 2014
Length of Fish : 2.63 cm (representative group of 10 fish, 3 days prior to beginning of exposure)
Body Weight of Fish : 0.164 g/fish (representative group of 10 fish, 3 days prior to beginning of exposure)
Temperature of Culture : 24.7 - 24.9 °C
Mortalities during period 7-days prior to Start of Study : 0%
Food : TetraMin, ad libitum - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 254 - 264 mg/L of CaCO3
- Test temperature:
- 21.1 to 23.9 °C
- pH:
- pH 7.7
- Dissolved oxygen:
- 7.5 - 8.5 mg O2/L
- Conductivity:
- 692 microS/cm2
- Nominal and measured concentrations:
- The water samples were simultaneously analysed for the residue of the Parent, and the corresponding alcohol (GR-88-1108) and acid (GR-88-1910).
NYMPHEAL was not stable in the exposure solutions over the 24-hour renewal period. The concentrations determined in the Fresh medium samples varied in the range of 68 to 103 % of Nominal, and, 33 - 86% of Nominal in the 24 hour old medium.
The Time-Weighted Mean Measured concentrations of the Parent over the 96-hour exposure period were, as follows :
Exposure Level Time-Weighted Mean Concn.
Control Not Detected
Solvent Control Not Detected
C1 (0.48 mg/L) 0.293 mg/L
C2 (0.86 mg/L) 0.489 mg/L
C3 (1.54 mg/L) 0.986 mg/L
C4 2.78 mg/L) 2.29 mg/L
C5 (5.00 mg/L) 4.34 mg/L
Small amounts of the Acid Metabolite were detected in the 24 hour aged samples, and, higher quantities of the Alcohol metabolite. Although total equivalent concentrations ahve been reported in the Final report, the end-points reported hereinare related to Parent, only. - Details on test conditions:
- Exposure Vessels : Fish exposed in 4 L glass tanks, depth of test solutio 15.2 cm, 7 fish per tank;
Fish Loading : 0.287 g/L
Length of Fish : 2.631 cm
Average Body Weight : 0.164 g/fish
Renewal : Every 24-hours at 24, 48 and 72 hours
Feeding : None
Photoperiod : Light/Dark 12h/12h
Light Intensity : 457 - 980 Lux
Aeration : Gentle aeration (permanent) - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.09 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% Confidence Interval : 0.546 - 1.72 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.489 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- other:
- Remarks:
- Absence of any sub-lethal observed effects.
- Details on results:
- A dose-response Relationship was observed.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 hour LC50 observed for D. rerio exposed to NYMPHEAL is 1.09 mg/L.
- Executive summary:
The 96 hour LC50 observed for D. rerio exposed to NYMPHEAL is 1.09 mg/L
.
Reference
Description of key information
OECD 203 - Acute Fish Toxicity :
LC50 (96 hr) (Danio rerio) = 1.09 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.09 mg/L
Additional information
OECD 203 - Acute Fish Toxicity :
LC50 (96 hr) (Danio rerio) = 1.09 mg/L
.
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