Registration Dossier
Registration Dossier
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EC number: 443-800-9 | CAS number: 40031-31-0
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- (S)-1,3,4-trihydroxybutan-2-one
- Type of composition:
- boundary composition of the substance
- State / form:
- liquid
- Reference substance:
- (S)-1,3,4-trihydroxybutan-2-one
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The substance is readily biodegradable.
Erythrulose undergoes 77% biodegradation after 28 days in the test conditions. The 10- day window criterion is also fulfilled (11% biodegradation on day 5 and 67% on day 15).
In an Acute Toxicity Study according to ISO International Standard 7346-1, EEC directive 92/69, Part C.1 and OECD TG 202 with Carp (Cyprinus carpio) the 96h-LC50 of the test item was determined to be > 100 mg/L (nominal).
Under the conditions of the present study (S)-1,3,4-trihydroxybutan-2-one did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC).
(S)-1,3,4-trihydroxybutan-2-one did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC).No inhibition of cell growth or reduction of growth rate was recorded at any of the concentrations of (S)-1,3,4-trihydroxybutan-2-one tested.
Hence, the EC50 for both cell growth inhibition and growth rate reduction was above 100 mg/l, the regulatory limit concentration.The partition coefficient (n-octanol/water) of Erythrulose was determined to be 7x10-3 (log P0= -2.16) at 20.0 ± 1.0°C using the Flask-shaking method.
Reference
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