trans-2-(4-Bromo-3-fluorophenyl)-5-butyl-[1,3]dioxane

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2018-10-11 to 2019-01-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Deviations:

no

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction

Deviations:

no

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Percentile:

D10

Mean:

26.3 µm

St. dev.:

0.14

Key result

Percentile:

D50

Mean:

151 µm

St. dev.:

0.28

Percentile:

D90

Mean:

439 µm

St. dev.:

10.61

The median particle size D50 (D (v, 0.5): 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D50 = 150.7 µm

2nd test series: D50 = 151.1 µm

The average of the median particle size D50 was: D50 = 151 µm

The particle size D10 (D (v,0.1): 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D10 = 26.4 µm

2nd test series: D10 = 26.2 µm

The average of the particle size D10 was: D10 = 26.3 µm

The particle size D90 (D (v, 0.9): 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D90 = 446 µm

2nd test series: D90 = 431 µm

The average of the particle size D90 was: D90 = 439 µm

The particle size distribution showed a monomodal distribution with a shoulder at approx. 6 - 7 µm. The maximum was observed at approx. 200 µm.

Conclusions:

The median particle sizes D10, D50 and D90 were determined to be 26.3 µm, 151 µm and 439 µm, respectively.

Executive summary:

A study was conducted according to OECD TG 110, CIPAC MT 187 and ISO 13320 to determine the particle size distribution of the test item. The test item consisted of transparent crystalline particles. The test item was sieved with a mesh size of 1000 µm. 59 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction. The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bars). After passing the analyser beam the sample was collected in a vacuum cleaner. Two test series of three measurements each were performed. The measurement time was 8 s. The median particle sizes D10, D50 and D90 were determined to be 26.3 µm, 151 µm and 439 µm, respectively.

Description of key information

The median particle sizes D10, D50 and D90 were determined to be 26.3 µm, 151 µm and 439 µm, respectively.

Additional information

A study was conducted according to OECD TG 110, CIPAC MT 187 and ISO 13320 to determine the particle size distribution of the test item (reference 4.5-1). The test item consisted of transparent crystalline particles. The test item was sieved with a mesh size of 1000 µm. 59 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction. The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bars). After passing the analyser beam the sample was collected in a vacuum cleaner. Two test series of three measurements each were performed. The measurement time was 8 s. The median particle sizes D10, D50 and D90 were determined to be 26.3 µm, 151 µm and 439 µm, respectively.