Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 609-276-2 | CAS number: 3663-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
General information: Remove affected person from source of contamination.
Inhalation: Move affected person to fresh air and keep warm and at rest in a position comfortable for breathing.
Ingestion: If swallowed do not induce vomiting. Clean mouth with water and drink afterwards plenty of water. Seek medical advice.
Skin contact: Wash skin thoroughly with soap and water for several minutes. Get medical attention promptly if symptoms occur after washing.
Eye contact: Immediately flush with plenty of water for up to 15 minutes. Remove any contact lenses and open eyelids widely. If irritation persists: Seek medical attention and bring along these instructions.
Protection of first aiders: First aid personnel should wear appropriate protective equipment during any rescue.
Fire-fighting measures
Suitable extinguishing media: Use fire-extinguishing media appropriate for surrounding materials. Extinguish with foam, carbon dioxide, dry powder or water fog.
Special hazards arising from the substance or mixture
- Hazardous combustion products: Oxides of carbon.
Advice for fire fighter
- Protective actions during firefighting: Avoid the spillage or runoff entering drains, sewers or watercourses.
- Special protective equipment for firefighters: Wear self contained breathing apparatus and fire kit.
Accidental release measures
Personal precautions: For personal protection, see Exposure Controls/personal protection below.
Environmental precautions: Avoid release to the environment.
Methods for cleaning up: Wear suitable personal protective equipment. Contain spillage if possible, take up mechanically avoiding formation of dust (e.g sweep up). Place in suitable closed containers for disposal as hazardous waste.
Reference to other sections: For personal protection, see Exposure Controls/personal protection below. For waste disposal, see Disposal considerations below.
Handling and storage
Precautions for safe handling
- Usage precautions: Wear suitable protective equipment, including gloves, goggles/face shield, respirator, boots, clothing or apron, as appropriate.
- Advice on general occupational hygiene: Good personal hygiene procedures should be implemented.
Storage precautions: Store at room temperature.
Specific end use(s): The identified uses for this product are pharmaceutical intermediate.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Control parameters
- Occupational exposure limits: No occupational exposure limit has been set for this substance.
Exposure controls
- Appropriate engineering controls: Use process enclosures, local exhaust ventilation or other engineering controls as the primary means to minimise worker exposure.
- Personal protection: Avoid inhalation, ingestion and contact with skin, eye and clothing.
- Eye/face protection: Use approved safety goggles or glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
- Hand protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 2016/425 and the standard EN 374 derived from it.
- Other skin and body protection: Protective overalls.
- Hygiene measures: Remove contaminated clothing and wash the skin thoroughly with soap and water after work.
- Respiratory protection: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Stability and reactivity
Reactivity: There are no known reactivity hazards associated with this product.
Stability: Stable under normal conditions of use.
Possibilityof hazardous reactions: Not determined.
Conditions to avoid: Avoid excessive heat for prolonged periods of time.
Materials to avoid: Strong oxidising agents.
Hazardous decomposition products: Oxides of carbon.
Disposal considerations
Waste treatment methods
- General information: Waste is classified as hazardous waste. Disposal to licensed waste disposal site in accordance with national and local authority regulations.
- Disposal methods: Incineration using appropriate licensed facilities.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.